Results 121 to 130 of about 1,290,259 (315)

Structural identifiability and indistinguishability analyses of glucose-insulin models [PDF]

In this thesis, the structural identifiability analyses of established and novel glucose-insulin models was performed, to determine whether the models are globally structurally identifiable with the observations available.
Chin, Sze Vone
core  

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress [PDF]

, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core  

RUSS-AGE study: Markers of carbohydrate metabolism and their time course in different age groups of a healthy population of the Russian Federation

Consilium Medicum
Background. One of the important tasks of modern science is to search for key biomarkers of aging of various body systems. Parameters of carbohydrate metabolism play an essential role in maintaining vital activity.
Anna K. Ilyushchenko, Arina E. Veriaskina, Lubov V. Machekhina, Aleksandra A. Melnitskaia, Olga N. Tkacheva, Andrey A. Tyazhelnikov, Valeriy S. Polunin, Alexander V. Iumukian, Irina D. Strazhesko   +8 more
doaj   +1 more source

3D Bioprinted Breast Cancer‐Stroma Model with Tailored Migration‐Permissive Bioink Reveals Impact of Adipose‐Derived Stromal Cells on Cancer Cell Migration and Invasion Dynamics

Advanced Healthcare Materials, EarlyView.
A migration‐permissive bioink composed of methacrylated collagen type I and thiolated hyaluronic acid enables 3D bioprinting of breast cancer‐stroma models. Single‐cell tracking reveals that adipose stromal cells enhance tumor cell motility and stromal invasion, accompanied by collagen remodeling, and a shift in tumor cell morphology.
Sabrina Stecher, Joachim Schenk, Alessandro Cianciosi, Katherina Hemmen, David Böhringer, Franziska Dusi, Jessica Faber, Philipp Stahlhut, Benedikt Gantert, Emilie Rouenhoff, Annika Gmöhling, Tessa Lühmann, Jörg Teßmar, Jürgen Groll, Silvia Budday, Tomasz Jüngst, Ben Fabry, Katrin G. Heinze, Petra Bauer‐Kreisel, Torsten Blunk   +19 more
wiley   +1 more source

Acute Effects of Aerobic Endurance Training with Different Glycogen Levels on Some Biochemical Parameters in Football Players

Pamukkale Spor Bilimleri Dergisi
This study aims to determine the acute effects of aerobic endurance exercises performed at different body glycogen levels on biochemical parameters related to energy metabolism.
Serdar Şerare, Mahir Arslan, Meryem Otu, İdris Buğra Çerik, Ahmet Karadağ, Ömer Şenel   +5 more
doaj   +1 more source

Structural Guidance in 3D Microgel‐in‐Hydrogel Systems to Improve Chondrogenesis

Advanced Healthcare Materials, EarlyView.
The Anisogel, an anisotropic microgel‐in‐hydrogel system, guides chondrogenic differentiation of human mesenchymal stromal cells (hMSCs) modulated by the alignment and size of anisometric microgels. Chondrogenic markers are upregulated in an in vitro model and guided tissue infiltration is enhanced in a semi‐orthopedic mouse model due to the physico ...
Julia Kamp, Alisa C. Suturin, Claudia A. Garrido, Xiaole Tong, Jietao Xu, Nicole Kops, Lea‐Sophie Müller, Till Hülsmann, Abdolrahman Omidinia‐Anarkoli, Laura Klasen, Tamás Haraszti, Gerjo J. V. M. van Osch, Laura De Laporte   +12 more
wiley   +1 more source

Bridging the Gap: Using Wild African Elephant Metabolic, Reproductive, and Stress Hormone Profiles to Enhance Management in Human Care

Animals
Understanding hormone patterns in free-ranging African elephants can provide critical insights for the management of elephants in human care, particularly in addressing reproductive anomalies and the rising prevalence of obesity in zoo populations.
Kaitlyn M. Campbell, Chelsi J. Marolf, Peter E. Buss, Kari A. Morfeld   +3 more
doaj   +1 more source

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

Advanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh, Ava Dashti, Thomas E. Robinson, Robyn Gaffey, Richard Moakes, Neil Lagali, Liam Grover, Thomas Ritter   +7 more
wiley   +1 more source

Effect of Insulin on Aortic Rings Isolated from Wistar Rats [PDF]

, 2010
Background:Insulin increases nitric oxide (NO) production via the phosphatidylinositol 3-kinase(PI3K) pathway and endothelin( ET)-1 secretion via the mitogen-activated protein kinase( MAPK) pathwayin vascular endothelial cells.
Sohma, Ryouichi, Aso, Yoshimasa, Takebayashi, Kohzo, Naruse, Rika, Inukai, Toshihiko   +4 more
core   +1 more source

Antidiabetic activity of Averrhoa bilimbi fruit methanol extract through enhancement of GLUT4 protein expression in diabetes‐induced mice

Indonesian Journal of Biotechnology
GLUT4, the glucose transporter responsive to insulin, is primarily found in muscle and adipose tissues. Diabetes can result from impaired insulin secretion and sensitivity.
Greselita Yolanda Juniyanti, Hesti Oktapiani, Ahmad Ridwan   +2 more
doaj   +1 more source