Results 71 to 80 of about 1,467,524 (254)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Las Manifestaciones cutáneas relacionadas con Pre diabetes y Diabetes mellitus: lo que el médico no debe olvidar

Revista de Medicina e Investigación Universidad Autónoma del Estado de México
Skin lesions can provide an early indication of a patient’s glucose tolerance and may be the first sign of metabolic disturbance.
IVÁN RENATO ZÚÑIGA CARRASCO
doaj   +1 more source

Perioperative factors associated with hyperglycemia after pediatric cardiac surgery and impact of hyperglycemia on morbidity and mortality

The Turkish Journal of Pediatrics, 2018
This retrospective, observational, single-center study aimed to determine the perioperative factors associated with postoperative hyperglycemia (blood glucose level ≥126 mg/dl) and the impact of hyperglycemia on morbidity and mortality in a cohort of ...
Çağlar Ödek, Ercan Tutar, Adnan Uysalel, Can Ateş, Zeynep Eyileten, Tayfun Uçar, Ayhan Yaman, Nihan Yıldırım-Yıldız, Tanıl Kendirli, Semra Atalay   +9 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism [PDF]

, 2004
The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function.
Pljesa, Steva, Komadina, Ljiljana, Milic, Natasa, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Perunicic-Pekovic, Gordana   +5 more
core  

Insulin Degludec, The New Generation Basal Insulin or Just another Basal Insulin? [PDF]

, 2012
The advances in recombinant DNA technology have led to an improvement in the properties of currently available long-acting insulin analogs. Insulin degludec, a new generation ultra-long-acting basal insulin, currently in phase 3 clinical trials, has a ...
Sami N. Nasrallah, Reynolds, L. Raymond, Nasrallah, Sami N., L. Raymond Reynolds   +3 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Estimation of insulin sensitivity from continuous glucose monitoring and insulin pump data in type 1 diabetes [PDF]

, 2012
Diabetes mellitus is a disease characterized by chronic hyperglycemia either due to a lack of secretion of the hormone insulin (Type 1 Diabetes Mellitus, T1DM) or due to impaired action of this hormone (Type 2 Diabetes Mellitus, T2DM).
Ronca, Gabriele
core  

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2011
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Burgess, Laura A, Howlett, David R, Meakin, PJ, Vaanholt, Lobke M, Hamilton, DL, Vaanholt, Lobke M., Judy Latcham, Burgess, Laura A., Alison D. McNeilly, Burgess, LA, Michael L.J. Ashford, D. Lee Hamilton, Lobke M. Vaanholt, Kirsten A. Bannon, Ashford, MLJ, David R. Howlett, Speakman, John R, McNeilly, Alison D, Alex J. Harper, John R. Speakman, Ashford, Michael L J, Speakman, John R., Gallagher, J, Hamilton, David Lee, McNeilly, Alison D.; id_orcid, Hussain, Ishrut, Hamilton, D. Lee, Latcham, J, Harper, Alex J, Bannon, KA, McNeilly, AD, Jennifer Gallagher, Latcham, Judy, Howlett, DR, Ashford, Michael L. J.; id_orcid, Vaanholt, LM, Hussain, I, Gallagher, Jennifer, Harper, Alex J., Bannon, Kirsten A., Paul J. Meakin, Bannon, Kirsten A, Ishrut Hussain, Harper, AJ, Meakin, Paul J, Laura A. Burgess, Howlett, David R., Speakman, JR, Meakin, Paul J.   +48 more
core   +1 more source