Results 71 to 80 of about 2,632,133 (359)

Perioperative factors associated with hyperglycemia after pediatric cardiac surgery and impact of hyperglycemia on morbidity and mortality

The Turkish Journal of Pediatrics, 2018
This retrospective, observational, single-center study aimed to determine the perioperative factors associated with postoperative hyperglycemia (blood glucose level ≥126 mg/dl) and the impact of hyperglycemia on morbidity and mortality in a cohort of ...
Çağlar Ödek, Ercan Tutar, Adnan Uysalel, Can Ateş, Zeynep Eyileten, Tayfun Uçar, Ayhan Yaman, Nihan Yıldırım-Yıldız, Tanıl Kendirli, Semra Atalay   +9 more
doaj   +1 more source

Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]

, 2013
ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M, Bergman, Richard N, Goodarzi, Mark O, Haffner, Steven M, Hanley, Anthony J, Lee, C Christine, Lorenzo, Carlos, Norris, Jill M, Rotter, Jerome I, Stefanovski, Darko, Wagenknecht, Lynne E   +10 more
core   +2 more sources

Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020
Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of ...
Yohannes Tsegyie Wondmkun
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. [PDF]

, 2018
OBJECTIVE:Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after ...
Chondronikola, Maria, Klein, Samuel, Magkos, Faidon, Muehlbauer, Michael J, Newgard, Christopher B, Okunade, Adewole L, Patterson, Bruce W, Yoshino, Jun   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +5 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Autoantibodies directed against insulin receptor during the course of Castleman disease: a new case reaffirming autoimmune hypoglycemia as a relapse warning signal

European Journal of Case Reports in Internal Medicine
This case study presents the case of a 54-year-old human immunodeficiency virus (HIV)-positive male who developed type B insulin resistance syndrome (TBIRS) in conjunction with a relapse of human herpesvirus 8 (HHV8)-positive multicentric Castleman ...
Xavier Jannot, Martine Auclair, Martin Martinot, Amin Maazouzi, David Boutboul, Corinne Vigouroux, Yannick Dieudonné   +6 more
doaj   +1 more source

Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]

, 1997
The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E., Jacquinet, Claire, Peiffer, Ginette, Taché, Sylviane   +3 more
core   +1 more source