Results 81 to 90 of about 2,674,610 (386)

Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]

, 2012
Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun, Devaskar, Sherin U, Garg, Meena, Shin, Bo-Chul, Stout, David, Thamotharan, Manikkavasagar, Thamotharan, Shanthie   +6 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome [PDF]

, 2013
Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient.
Bonin, Cecilia, Bonora, Enzo, Dall'Alda, Marlene, Di Sarra, Daniela, Fiers, Tom, Giagulli, Vito Angelo, Kaufman, Jean, Moghetti, Paolo, Signori, Chiara, Spiazzi, Giovanna, Tosi, Flavia, Zambotti, Francesca, Zanolin, Maria Elisabetta   +12 more
core   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach [PDF]

, 2009
AIMS/HYPOTHESIS: Twin and family studies have shown the importance of genetic factors influencing fasting and 2 h glucose and insulin levels. However, the genetics of the physiological response to a glucose load has not been thoroughly investigated ...
AJ Hanley, B Benyamin, D Lann, E Zeggini, EJ Geus De, EJ Mayer, G. F. Liu, H Snieder, H Snieder, H Snieder, H. Riese, H. Snieder, J Baird, JM McCaffery, K Schousboe, L Gaal Van, M Lehtovirta, M Lehtovirta, M. Mangino, MCBS Neale, MCCL Neale, NJ Samani, NY Souren, P Poulsen, P Poulsen, Q Qiao, R. P. Stolk, S Katoh, S. D. O’Dell, SM Haffner, T Andrew, T. D. Spector, TD Gould, TD Spector, The DECODE Study Group, TM Frayling, World Health Organization   +36 more
core   +4 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Autoantibodies directed against insulin receptor during the course of Castleman disease: a new case reaffirming autoimmune hypoglycemia as a relapse warning signal

European Journal of Case Reports in Internal Medicine
This case study presents the case of a 54-year-old human immunodeficiency virus (HIV)-positive male who developed type B insulin resistance syndrome (TBIRS) in conjunction with a relapse of human herpesvirus 8 (HHV8)-positive multicentric Castleman ...
Xavier Jannot, Martine Auclair, Martin Martinot, Amin Maazouzi, David Boutboul, Corinne Vigouroux, Yannick Dieudonné   +6 more
doaj   +1 more source

Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin

Drug Delivery, 2018
Carrier peptides, termed protein transduction domains (PTDs), serve as provide promising vehicles for intranasal delivery of macromolecular drugs. A mutant PTD derived from human translationally controlled tumor protein (TCTP-PTD 13, MIIFRALISHKK) was ...
Hae-Duck Bae, Joohyun Lee, Kyu-Yeon Jun, Youngjoo Kwon, Kyunglim Lee   +4 more
doaj   +1 more source

Impact of Pre-Processed Chickpea Flour Incorporation into “Mankoushe” on Appetite Hormones and Scores

Foods, 2018
Recently, there has been an increasing interest in integrating pulse flours into pastries and baked products to improve their nutritional and health benefits.
Sahar Dandachy, Hiba Mawlawi, Marwan Chedid, Carla El-Mallah, Omar Obeid   +4 more
doaj   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source