Results 51 to 60 of about 269,490 (301)

Determination of islet cell antibodies using an ELISA system with a preparation of rat insulinoma (RIN A2) cells [PDF]

, 1989
An enzyme-linked immunosorbent assay (ELISA) was established for the detection of islet cell antibodies in human sera. The antigen was prepared from rat insulinoma (RIN A2) cells.
Seißler, Jochen, Hedderich, U., Specker, M., Pfeiffer, Ernst Friedrich, Böhm, Bernhard Otto, Scherbaum, Werner A.   +5 more
core  

Autoreactive antibodies control blood glucose by regulating insulin homeostasis

, 2022
Homeostasis of metabolism by hormone production is crucial for maintaining physiological integrity, as disbalance can cause severe metabolic disorders such as diabetes mellitus.
Young, Marc, Allies, Gabriele, Warnatz, Klaus, Nicolò, Antonella, Ayoubi, Omar El, El Ayoubi, Omar, Amendt, Timm, Jumaa, Hassan, Setz, Corinna, Röszer, Tamás   +9 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2019
The present work was planned to find a correlation between HCV infection and diabetes mellitus (DM) incidence in Egyptian patients by finding a possible relationship between HCV antibodies and both anti-insulin antibodies (AIAs) and pancreatic islet cell
Yousry El-Bolkiny, Mohamed Raghaey, Abdelhalim Alkhazendar, Merveet Mansour, Fuad Harras   +4 more
doaj   +1 more source

Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome [PDF]

, 1993
Cytoplasmic islet cell antibodies are well-established predictive markers of IDDM. Although target molecules of ICA have been suggested to be gangliosides, human monoclonal ICA of the immunoglobulin G class (MICA 1-6) produced from a patient with newly ...
Seißler, Jochen, Meinck, Hans-Michael, Wolfahrt, S., Northemann, Wolfgang, Scherbaum, Werner A., Richter, Wiltrud   +5 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus

مجلة علوم ذي قار
  Insulin antibodies (INAs) are found in both types of diabetic patients and have low binding capacity and high affinity leading to hypoglycemia or hyperglycemia in type II patients taking insulin, which differs from the insulin antibodies found in type ...
Joumana Sharad, Hind Mousa
doaj   +1 more source

Prevalence of Autoantibodies in Type 1 Diabetes Mellitus and the Clinical Utility of Diabetes Antibody Testing in the Indian Population: A Retrospective Study of 3 Years [PDF]

Indian Journal of Medical Biochemistry
Background: Type 1 diabetes or insulin-dependent diabetes is rising at 2–3% per year and contributes to almost 90% of juvenile diabetes and 10% of adult-onset diabetes.
Flavia Almeida, Alap Christy, Raj Jatale, Nilam Tripathi, Lynda Rodrigues   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Circulating insulin-binding antibodies [PDF]

Diabetologia, 1980
Insulin was first used in the treatment of diabetic patients in 1921 and the first immunological problem associated with its use was reported in 1922 [1]; a patient developed anaphylaxis after the injection of a porcine, but not of a bovine insulin preparation.
A B, Kurtz, J D, Nabarro
openaire   +2 more sources