Results 1 to 10 of about 115,305 (240)

Immunoreactive insulin stability in horses at risk of insulin dysregulation [PDF]

Journal of Veterinary Internal Medicine, 2019
Background Diseases associated with insulin dysregulation (ID), such as equine metabolic syndrome and pituitary pars intermedia dysfunction, are of interest to practitioners because of their association with laminitis.
Dakota H. Leschke, Genevieve S. Muir, Jack K. Hodgson, Mitchell Coyle, Remona Horn, François‐René Bertin   +5 more
doaj   +6 more sources

Carbohydrate pellets to assess insulin dysregulation in horses [PDF]

Journal of Veterinary Internal Medicine, 2023
Background A glycemic challenge test is used for the diagnosis of insulin dysregulation (ID) in horses and ponies. Different forms of the test exist where the administrative route and dose of glucose vary, which makes interpretation of results ...
Melody A. deLaat, Tobias Warnken, Julien Delarocque, Dania B. Reiche, Anne J. Grob, Karsten Feige, Harry B. Carslake, Andy E. Durham, Martin N. Sillence, Kristen E. Thane, Nicholas Frank, Johan Brojer, Sanna Lindase, Johanna Sonntag   +13 more
doaj   +5 more sources

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation [PDF]

Journal of Veterinary Internal Medicine
Background Phenylbutazone is often prescribed to manage pain caused by hyperinsulinemia‐associated laminitis, but in diabetic people nonsteroidal anti‐inflammatory drugs increase insulin secretion and pancreatic activity.
Kate L. Kemp, Jazmine E. Skinner, François‐René Bertin   +2 more
doaj   +5 more sources

Effect of Phenylbutazone Administration on Insulin Sensitivity in Horses With Insulin Dysregulation [PDF]

Journal of Veterinary Internal Medicine
Background Phenylbutazone is prescribed to manage pain caused by hyperinsulinemia‐associated laminitis. Phenylbutazone reduces glucose and insulin concentrations in horses with insulin dysregulation (ID) but the underlying mechanism of action is unknown.
Kate L. Kemp, Nicholas K. Y. Yuen, Jazmine E. Skinner, François‐René Bertin   +3 more
doaj   +4 more sources

The effects of obesity and insulin dysregulation on mare reproduction, pregnancy, and foal health: a review [PDF]

Frontiers in Veterinary Science, 2023
Obesity is a growing welfare concern in modern equine populations and predisposes horses to disturbances in energy metabolism such as insulin dysregulation. However, equine metabolic syndrome has only been recognized in recent decades. Functioning energy
Isa Hallman, Ninja Karikoski, Maria Kareskoski   +2 more
doaj   +2 more sources

Lower plasma trans-4-hydroxyproline and methionine sulfoxide levels are associated with insulin dysregulation in horses [PDF]

BMC Veterinary Research, 2018
Background Insulin dysregulation in horses is a metabolic condition defined by high insulin concentrations in the blood and peripheral insulin resistance. This hyperinsulinemia is often associated with severe damage in the hooves, resulting in laminitis.
Ákos Kenéz, Tobias Warnken, Karsten Feige, Korinna Huber   +3 more
doaj   +2 more sources

Insulin dysregulation in horses with induced obesity [PDF]

Pesquisa Veterinária Brasileira, 2020
: Insulin deregulation (ID) is a central player in the pathophysiology of equine metabolic syndrome (EMS), which is associated with generalized and/or regional obesity.
Rodrigo M. Ribeiro, Debora S.F. Ribeiro, Cahuê Francisco R. Paz, Alexandre A.O. Gobesso, Rafael R. Faleiros   +4 more
doaj   +4 more sources

mTOR Dysregulation, Insulin Resistance, and Hypertension

Biomedicines
Worldwide, diabetes mellitus (DM) and cardiovascular diseases (CVDs) represent serious health problems associated with unhealthy diet and sedentarism. Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, insulin resistance (
Silviu Marcel Stanciu, Mariana Jinga, Daniela Miricescu, Constantin Stefani, Remus Iulian Nica, Iulia-Ioana Stanescu-Spinu, Ileana Adela Vacaroiu, Maria Greabu, Silvia Nica   +8 more
doaj   +3 more sources

ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. [PDF]

J Clin Invest
BACKGROUNDThis study examined the underlying cellular mechanisms associated with insulin resistance (IR) and metabolic disease risk within subcutaneous adipose tissue (SAT) in youth with obesity and IR compared with those without IR.METHODSThirteen adolescents who were insulin sensitive (IS) and 17 adolescents with IR and obesity underwent a 3-hour ...
Slusher AL, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner DF, Shulman GI, Caprio S.   +11 more
europepmc   +4 more sources

Effect of 5′‐adenosine monophosphate‐activated protein kinase agonists on insulin and glucose dynamics in experimentally induced insulin dysregulation in horses [PDF]

Journal of Veterinary Internal Medicine
Background 5′‐adenosine monophosphate‐activated protein kinase (AMPK) agonists, particularly resveratrol (RES), have not been extensively evaluated for their effect on insulin dysregulation (ID) in horses.
Erin F. Pinnell, Laura D. Hostnik, Mauria R. Watts, Kathryn J. Timko, Allison A. Thriffiley, Mercedes R. Stover, Lauren E. Koenig, Olivia M. Gorman, Ramiro E. Toribio, Teresa A. Burns   +9 more
doaj   +2 more sources