Results 151 to 160 of about 1,795,545 (198)

Engineered insulin-polycation complexes for glucose-responsive delivery with high insulin loading

Journal of Controlled Release, 2021
Glucose-responsive insulin delivery systems have the potential to improve quality of life for individuals with diabetes by improving blood sugar control and limiting the risk of hypoglycemia. However, systems with desirable insulin release kinetics and high loading capacities have proven difficult to achieve.
Lisa R, Volpatti, Delaney M, Burns, Arijit, Basu, Robert, Langer, Daniel G, Anderson   +4 more
openaire   +2 more sources

Breakfast and dinner insulin index and insulin load in relation to overweight in children and adolescents

European Journal of Nutrition, 2021
Hyperinsulinemia is related to the development of several chronic diseases, particularly obesity. Therefore, this study aimed to examine the association between the insulinemic potential of both total diet and meals, measured by the glycemic index (GI), glycemic load (GL), insulin index (II), and insulin load (IL), and overweight risk among children ...
Zeynep Caferoglu, Busra Erdal, Leyla Akin, Selim Kurtoglu   +3 more
openaire   +3 more sources

The association between dietary insulin index and dietary insulin load with rheumatoid arthritis

British Journal of Nutrition, 2023
AbstractThis study was designed to assess the relationship between dietary insulin index (DII) and dietary insulin load (DIL) and rheumatoid arthritis (RA) risk in a case–control study. This study enrolled ninety-five newly diagnosed RA patients and 200 age- and sex-matched healthy controls. Dietary intakes were assessed using a validated 168-item semi-
Mohadeseh Soleimani Damaneh, Naheed Aryaeian, Shole Khajoenia, Leila Azadbakht, Fatemeh Sadat Hosseini-Baharanchi   +4 more
openaire   +2 more sources

Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin

Journal of Controlled Release, 2023
Compared to subcutaneous injections, oral administration of insulin would be a preferred route of drug administration for diabetic patients. For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug and poor intestinal drug absorption.
Haishan, Wu, Jian, Nan, Liu, Yang, Hyun Jin, Park, Jinglei, Li   +4 more
openaire   +2 more sources

Insulin-Loaded Microcapsules for In Vivo Delivery

Molecular Pharmaceutics, 2009
Microencapsulation of insulin has been difficult, due to the high sensitivity of insulin to the harsh conditions that can occur during the microencapsulation process. We have developed a method of preparing insulin-loaded microcapsules by using a monoaxial ultrasonic atomizer to form microdroplets of insulin in aqueous solution surrounded by poly ...
Byung Soo, Kim, Jae Min, Oh, Hoon, Hyun, Kyung Sook, Kim, Sang Hyo, Lee, Yu Han, Kim, Kinam, Park, Hai Bang, Lee, Moon Suk, Kim   +8 more
openaire   +2 more sources

Impaired insulin signalling and allostatic load in Alzheimer disease

Nature Reviews Neuroscience, 2022
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way for numerous studies on hormone signalling networks and actions in peripheral tissues and in the central nervous system. Impaired insulin signalling, a hallmark of diabetes, is now established as a key component of Alzheimer disease (AD) pathology.
Fernanda G. De Felice, Rafaella A. Gonçalves, Sergio T. Ferreira   +2 more
openaire   +2 more sources

Glucose and insulin levels on loading with different carbohydrates

Clinica Chimica Acta, 1975
Normal subjects were given, on separate occasions, equivalent amounts of glucose, surcrose (""sugar''), and carbohydrates in the form of bread and starch. Neither the glucose, nor the insulin values showed any significant difference in these persons after they had been loaded with the various carbohydrates.
A, Lütjens, H, Verleur, M, Plooij
openaire   +2 more sources

Insulin-loaded hydroxyapatite combined with macrophage activity to deliver insulin for diabetes mellitus

Journal of Materials Chemistry B, 2015
InsHAP is engulfed by macrophages and the lysosome/endosome hybrid is broken down by osmosis, which facilitates delivery of insulin into the bloodstream.
Yen-Jye, Shyong, Cheng-Chia, Tsai, Rui-Feng, Lin, Hung-Sheng, Soung, Hui-Chen, Hsieh, Yu-Sheng, Hsueh, Kuo-Chi, Chang, Feng-Huei, Lin   +7 more
openaire   +2 more sources

Glycaemic Load Versus Carbohydrate Counting for Insulin Bolus Calculation in Patients With Type 1 Diabetes on Insulin Pump

Acta Diabetologica, 2015
To evaluate feasibility and effectiveness on short-term blood glucose control of using glycaemic load counting (GLC) versus carbohydrate counting (CC) for prandial insulin dosing in patients with type 1 diabetes (T1D)
Gabriele Riccardi, G Annuzzi, L Bozzetto
exaly   +2 more sources

Revolutionizing Diabetes Treatment with Insulin-loaded Nanoparticles

Mini-Reviews in Medicinal Chemistry
Diabetes mellitus is a disease characterised by elevated blood glucose levels, with its major subtypes being type 1 (immune-mediated) and type 2 (lifestyle-related) diabetes. Medical treatment for diabetes requires patients to perform subcutaneous insulin injections since oral insulin faces problems with ...
Jatin Vats, Anjali Rana, Ajesh Chauhan, Shivam Rajput, Rishabha Malviya, Chetan Vashist, Arun Mittal, Sathvik Belagodu Sridhar   +7 more
openaire   +2 more sources