Results 161 to 170 of about 1,795,545 (198)
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Evidence for restrictive parameters in formulation of insulin-loaded nanocapsules
European Journal of Pharmaceutics and Biopharmaceutics, 2004Poly(isobutylcyanoacrylate) nanocapsules with an oily core were originally proposed for lipophilic drug encapsulation [Int. J. Pharm. 28 (1986) 125] but insulin, a hydrosoluble protein, has also been successfully encapsulated by Damgé et al. [Diabetes 37 (1988) 246].
Fabienne, Cournarie +3 more
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Insulin sensitivity predicts glycemia after a protein load
Metabolism, 2000Protein ingestion results in small but distinct changes in plasma glucose and insulin. We hypothesized that the glycemic and/or insulin response to protein might be related to the degree of insulin sensitivity. Our aim was to determine the relationships between insulin sensitivity (assessed by euglycemic-hyperinsulinemic clamp) and postprandial glucose,
J C, Brand-Miller +2 more
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GTP Loading of Farnesylated p21Ras by Insulin at the Plasma Membrane
Biochemical and Biophysical Research Communications, 1997Insulin promotes the phosphorylation and activation of farnesyltransferase (FTase) in a time- and a dose-dependent manner. Increased FTase activity results in a larger pool of farnesylated p21Ras and allows for enhanced GTP loading. Insulin significantly increases the pool of farnesylated p21Ras from 20-25% in quiescent 3T3-L1 fibroblasts to ...
M, Goalstone, J W, Leitner, B, Draznin
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[Insulin secretion and utilization of insulin in piglets after insulin, arginine and glucose loads].
Polskie archiwum weterynaryjne, 1987The insulin secretion and utilization dynamics have been investigated in 35 six weeks old healthy piglets in order to find the connection with spontaneous hypoglycemia. The trial to load piglets with insulin showed an average time t1/2 = 4.93 minutes accepted as normal in 10 piglets with the mean increase in body weight equal to 0.19 kg/day, prolonged ...
J, Nowak, J, Kania
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Oral Delivery of Insulin Loaded into Polymeric Nanoparticles in Rats
Drug Delivery Letterse, 2011Diabetes prevalence is steadily increasing and both type 1 and type 2 contribute to this “diabetes epidemic”. Insulin is the sole therapeutic, life-saving option for type 1 diabetes with patients self-injecting the hormone every day for life. In this study, insulin has been loaded into polymeric nanoparticles (Np) of poly (D,L-lactide-co-glycolide) and
TOSI, Giovanni +9 more
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International Journal of Pharmaceutics, 2002
Poly(isobutylcyanoacrylate) nanocapsules have been shown to decrease the blood glucose level after oral administration to streptozotocin-induced diabetic fasted rats after 2 days [Diabetes 37 (1988) 246]. Yet, the absorption of insulin in the blood of rats has not been characterised.
F, Cournarie +5 more
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Poly(isobutylcyanoacrylate) nanocapsules have been shown to decrease the blood glucose level after oral administration to streptozotocin-induced diabetic fasted rats after 2 days [Diabetes 37 (1988) 246]. Yet, the absorption of insulin in the blood of rats has not been characterised.
F, Cournarie +5 more
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Modulating postoperative insulin resistance by preoperative carbohydrate loading
Best Practice & Research Clinical Anaesthesiology, 2009The concept of preoperative overnight fasting was challenged and proved to have no benefits over allowing patients to drink clear fluids up until 2 h before surgery. This led to changes in the guidelines for preoperative fasting in many countries around the world. This concept has more recently been developed further.
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INSULIN RESPONSE TO GLUCOSE LOADING IN ACROMEGALY
The Lancet, 1964E, CERASI, R, LUFT
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A review on insulin loaded microneedles for diabetes management
International Journal of Clinical Pharmacokinetics and Medical SciencesMicroneedles (MNs) have been extensively investigated as a promising technique to enhance transdermal drug delivery by physically breaching the skin barrier. The stratum corneum, the outermost layer of the skin, acts as a strong barrier, especially against large or hydrophilic molecules.
{\\"name\\":\\"Sujatha Sanneboina\\",\\"email\\":\\"drsannenoina@gmail.com\\",\\"affiliation\\":\\" +5 more
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Dietary Insulin Index and Insulin Load in Relation to Glioma: Findings From a Case–Control Study
Nutritional Neuroscience, 2021Javad Anjom-Shoae +2 more
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