Results 51 to 60 of about 3,468,934 (422)

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Science, 2001
The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found
D. Clancy, D. Gems, L. Harshman, S. Oldham, Hugo Stocker, E. Hafen, S. Leevers, L. Partridge   +7 more
semanticscholar   +1 more source

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources

Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

EMBO Journal, 1986
To identify structural characteristics of the closely related cell surface receptors for insulin and IGF‐I that define their distinct physiological roles, we determined the complete primary structure of the human IGF‐I receptor from cloned cDNA.
A. Ullrich, A. Gray, A. W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Bon, S. Kathuria, E. Chen, S. Jacobs, U. Francke, J. Ramachandran, Y. Fujita‐Yamaguchi   +13 more
semanticscholar   +1 more source

Insulin analogs and cancer

Frontiers in Endocrinology, 2012
Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca, Rosario eLe Moli, Riccardo eVigneri   +2 more
doaj   +1 more source

Security, extensibility, and redundancy in the Metabolic Operating System [PDF]

arXiv, 2023
People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to monitor their metabolic state and an insulin pump device to adjust insulin to adapt.
arxiv  

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

Nature Communications, 2013
The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes.
I. Kimura, K. Ozawa, D. Inoue, Takeshi Imamura, K. Kimura, Takeshi Maeda, Kazuya Terasawa, Daiji Kashihara, Kanako Hirano, T. Tani, Tomoyuki Takahashi, Satoshi Miyauchi, G. Shioi, H. Inoue, G. Tsujimoto   +14 more
semanticscholar   +1 more source

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain [PDF]

, 2019
Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand-receptor interactions ...
Adams, Afonine, Alvarado, Baker, Bartoschik, Bass, Beate Brankatschk, Belfiore, Bussi, Chetan Poojari, Chiacchia, Christiansen, Conway, Coskun, Croll, Danne, Darden, De Meyts, De Meyts, De Meyts, De Meyts, de Meyts, De Meyts, Delle Bovi, DeMeyts, Durocher, Emsley, Endres, Essmann, Eswar, Ferguson, Fernandes de Abreu, Fleishman, Freed, Garofalo, Gasteiger, Goddard, Gutmann, Gutmann, Hess, Hess, Horwitz, Hoyne, Hua, Humphrey, Ilpo Vattulainen, Ingmar B. Schäfer, Jiráček, Jorgensen, Kaminski, Kasuga, Kaszuba, Kavran, Kimanius, Kiselyov, Kleinridders, Lata, Lax, Leray, Longo, Luo, Mastronarde, McGreevy, McKern, Menting, Menting, Mike Strauss, Muggeo, Parrinello, Parrinello, Parrinello, Pettersen, Rentería, Rigaut, Rosenthal, Saltiel, Scapin, Schäffer, Seidel, Sparrow, Sparrow, Sparrow, Subramanian, Tatulian, Theresia Gutmann, Trabuco, Tranum-Jensen, Uchikawa, Wang, Weis, Weiss, Whittaker, Whittaker, Woldin, Xu, Xu, Ye, Zhang, Zheng, Zivanov, Ünal Coskun   +100 more
core   +2 more sources

The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes [PDF]

, 1991
We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes.
Drenkhan, M., Klein, H. H., Matthaei, S., Ries, W., Scriba, Peter Christian   +4 more
core  

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source