Results 1 to 10 of about 399,223 (393)
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis [PDF]
eLife, 2021 The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been ...
Alison L Kearney +14 more
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Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor [PDF]
Bio-Protocol, 2023 Far-western blotting, derived from the western blot, has been used to detect interactions between proteins in vitro, such as receptor–ligand interactions.
Jinghua Peng +3 more
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Reduced Tyrosine and Serine-632 Phosphorylation of Insulin Receptor Substrate-1 in the Gastrocnemius Muscle of Obese Zucker Rat [PDF]
Current Issues in Molecular Biology, 2022 Obesity has become a serious health problem in the world, with increased morbidity, mortality, and financial burden on patients and health-care providers. The skeletal muscle is the most extensive tissue, severely affected by a sedentary lifestyle, which
Mohammad Shamsul Ola
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Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling [PDF]
JCI Insight, 2020 Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1 (IRS1), the present study tested the hypothesis that ...
Christian Riehle +18 more
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Journal of Biological Chemistry, 1994 Treatment of cells with okadaic acid, a protein phosphatase inhibitor, leads to an insulin-resistant state without modification in the tyrosine kinase activity of the receptor toward exogenous substrates. In 3T3-L1 adipocytes, okadaic acid induced a similar dose-dependent inhibition of the insulin effect on deoxyglucose uptake, phosphatidylinositol 3 ...
J F, Tanti +3 more
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Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function
Frontiers in Endocrinology, 2021 Mutations of the insulin-like receptor in Drosophila extend lifespan. New research suggests this receptor operates in two modes. The first extends lifespan while slowing reproduction and reducing growth.
Marc Tatar
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Frontiers in Molecular Biosciences, 2023 Noncommunicable diseases (NCDs), such as diabetes and related neurological disorders, are considered to not be directly transmissible from one person to another. However, NCDs may be transmissible in vivo through extracellular vesicles (EVs). A long-term
Biao Li +3 more
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Pengaruh Latihan Fisik terhadap Perbaikan Resistensi Insulin
Keluwih, 2021 --Insulin resistance underlies the pathogenesis of chronic disease, such as diabetes mellitus which has high morbidity and mortality rate. Insulin resistance is a pathological condition when cells fail to respond normally to the insulin hormone, because ...
Devitya Angielevi Sukarno
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Peranan Resveratrol terhadap Progresivitas Uterine Fibroid
Keluwih, 2021 --Insulin resistance underlies the pathogenesis of chronic disease, such as diabetes mellitus which has high morbidity and mortality rate. Insulin resistance is a pathological condition when cells fail to respond normally to the insulin hormone, because ...
Made Indira Dianti Sanjiwani +1 more
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Neural Regeneration Research, 2021 In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown.
Hui Yang +5 more
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