Results 91 to 100 of about 399,223 (393)

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance

The Application of Clinical Genetics, 2018
Anas A Yousef,1 Eman G Behiry,1 Wafaa M Abd Allah,1 Ahmed M Hussien,2 Abdelmoneam A Abdelmoneam,2 Mahmoud H Imam,2 Doaa M Hikal,1 1Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Benha, Egypt; 2Department of ...
Yousef AA, Behiry EG, Abd Allah WM, Hussien AM, Abdelmoneam AA, Imam MH, Hikal DM   +6 more
doaj  

Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons

BMC Neuroscience, 2007
Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G, Persiyantseva Nadezhda A, Senilova Yana E, Storozhevykh Tatiana P, Pomytkin Igor A   +4 more
doaj   +1 more source

Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice

Communications Biology, 2022
Re-expression of the insulin receptor substrate p53 (IRSp53) in adult IRSp53-mutant mice rescues behavioral and synaptic deficits, suggesting that adult re-expression may hold future therapeutic potential.
Young Woo Noh, Chaehyun Yook, Jaeseung Kang, Soowon Lee, Yeonghyeon Kim, Esther Yang, Hyun Kim, Eunjoon Kim   +7 more
doaj   +1 more source

Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways. [PDF]

, 2014
Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related ...
Attardo, Geoffrey M, Drake, Lisa L, Hansen, Immo A, Rodriguez, Stacy D   +3 more
core   +2 more sources

Visceral Adipose Tissue Inflammatory Factors (TNF-Alpha, SOCS3) in Gestational Diabetes (GDM): Epigenetics as a Clue in GDM Pathophysiology [PDF]

, 2020
Gestational diabetes (GDM) is among the most challenging diseases in westernized countries, affecting mother and child, immediately and in later life. Obesity is a major risk factor for GDM.
Henrich, Wolfgang, Melchior, Kerstin, Ott, Raffael, Plagemann, Andreas, Rancourt, Rebecca C., Schellong, Karen, Ziska, Thomas   +6 more
core   +1 more source

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

PLoS ONE, 2011
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We
C. Selman, L. Partridge, D. Withers
semanticscholar   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Lack of Association of Insulin Receptor Substrate Gene Polymorphisms with Obstructive Sleep Apnea Syndrome

Medicine Science, 2013
Sleep apnea syndrome is associated with increased prevalence of diabetes and has recently shown to be associated with insulin resistance. The aim of the present study was to investigate the relationships between insulin resistance, insulin receptor ...
Fulden Sarac, Afig Berdeli, Ozen K. Basoglu, Sumru Savas, Merve Atan, Fehmi Akcicek   +5 more
doaj   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source