Results 151 to 160 of about 399,223 (393)

Molecular mechanisms of insulin receptor substrate protein‐mediated modulation of insulin signalling

FEBS Letters, 2003
The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated – both positively and negatively – at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of ...
Johnston, Anne M., Pirola, Luciano, Van Obberghen, Emmanuel   +2 more
openaire   +2 more sources

Different Subcellular Localization and Phosphoinositides Binding of Insulin Receptor Substrate Protein Pleckstrin Homology Domains [PDF]

, 2000
Giorgia Razzini, Alessandra Ingrosso, Anna Brancaccio, Salvatore Sciacchitano, Diana L. Esposito, Marco Falasca   +5 more
openalex   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis [PDF]

, 1996
Lynne Yenush, Rafael Fernández, Martin G. Myers, Timothy C. Grammer, Xiao‐Jian Sun, John Blenis, Jacalyn H. Pierce, Joseph Schlessinger, Morris F. White   +8 more
openalex   +1 more source

Research Progress in Wearable Microneedle Sensors for Health Analysis

Advanced Sensor Research, EarlyView.
Wearable biosensors are transforming personal healthcare by enabling minimally invasive, molecular‐level monitoring. Emerging electrochemical microneedle sensors can detect analytes in interstitial fluid, enabling painless extraction and real‐time tracking.
Adnan Zameer, Yang Guo, Hongda Wang, Qiang Zhang   +3 more
wiley   +1 more source

Supplementary Figure S1 from Nitric Oxide Inhibits the Proliferation and Invasion of Pancreatic Cancer Cells through Degradation of Insulin Receptor Substrate-1 Protein

, 2023
Hiroki Sugita, Masao Kaneki, Satoshi Furuhashi, Masahiko Hirota, Hiroshi Takamori, Hideo Baba   +5 more
openalex   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease. [PDF]

Metabol Open, 2023
Mima A, Murakami A, Lee R, Lee S.
europepmc   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Physiological and pathophysiological actions of insulin in the liver

Endocrine Journal
The liver plays an important role in the control of glucose homeostasis. When insulin levels are low, such as in the fasting state, gluconeogenesis and glycogenolysis are stimulated to maintain the blood glucose levels.
Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki   +2 more
doaj   +1 more source