Results 11 to 20 of about 399,223 (393)

IRS2 (insulin receptor substrate 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Insulin receptor substrate 2 (IRS2) belongs to the insulin receptor substrate protein family and was initially discovered as an alternative route for signaling mediated by the insulin receptor. Currently, IRS2 has been well-established to mediate mitogenic and antiapoptotic signaling from several important cellular receptors.
Machado-Neto, Joao Agostinho, de Melo Campos, Paula, Traina, Fabiola   +2 more
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Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis

Clinics, 2018
The insulin receptor substrate (IRS) proteins are a family of cytoplasmic proteins that integrate and coordinate the transmission of signals from the extracellular to the intracellular environment via transmembrane receptors, thus regulating cell growth,
João Agostinho Machado-Neto, Bruna Alves Fenerich, Ana Paula Nunes Rodrigues Alves, Jaqueline Cristina Fernandes, Renata Scopim-Ribeiro, Juan Luiz Coelho-Silva, Fabiola Traina   +6 more
doaj   +2 more sources

IRS1 (insulin receptor substrate 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on IRS1 (insulin receptor substrate 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Machado-Neto, JA, Traina, F
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Insulin Receptor Substrate 4 [PDF]

Definitions, 2020
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Insulin Receptor Substrate 1 [PDF]

Definitions, 2020
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Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy [PDF]

International Journal of Experimental Diabetes Research, 2011
Insulin signaling depends on tyrosine phosphorylation of insulin receptor substrates (IRSs) to mediate downstream effects; however, elevated serine phosphorylation of IRS impairs insulin signaling. Here, we investigated IRS protein expression patterns in
Caleb W. Grote, Jill K. Morris, Janelle M. Ryals, Paige C. Geiger, Douglas E. Wright   +4 more
openalex   +2 more sources

Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance

Molecular Psychiatry, 2020
Insulin signaling is critical for neuroplasticity, cerebral metabolism as well as for systemic energy metabolism. In rodent studies, impaired brain insulin signaling with resultant insulin resistance (IR) modulates synaptic plasticity and the ...
C. Nasca, Josh Dobbin, Benedetta Bigio, K. Watson, P. de Angelis, Marin M. Kautz, A. Cochran, A. Mathé, J. Kocsis, F. Lee, J. Murrough, B. McEwen, N. Rasgon   +12 more
semanticscholar   +1 more source

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog [PDF]

EMBO Journal, 1997
Stevan R. Hubbard
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Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

The FASEB Journal, 2014
Dimitrios Kapogiannis, Adam L. Boxer, Janice B. Schwartz, Erin L. Abner, Arya Biragyn, Umesh Masharani, Lynda Frassetto, Ronald C. Petersen, Bruce L. Miller, Edward J. Goetzl   +9 more
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Characterization of Drosophila Insulin Receptor Substrate [PDF]

Journal of Biological Chemistry, 2000
Insulin receptor substrate (IRS) proteins are phosphorylated by multiple tyrosine kinases, including the insulin receptor. Phosphorylated IRS proteins bind to SH2 domain-containing proteins, thereby triggering downstream signaling pathways. The Drosophila insulin receptor (dIR) C-terminal extension contains potential binding sites for signaling ...
R M, Poltilove, A R, Jacobs, C R, Haft, P, Xu, S I, Taylor   +4 more
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