Results 231 to 240 of about 399,223 (393)

Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review). [PDF]

Mol Med Rep
Tang W, Liu H, Li X, Deng S, Gao C.
europepmc   +1 more source

Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4. [PDF]

Front Endocrinol (Lausanne), 2021
Patyra K, Makkonen K, Haanpää M, Karppinen S, Viikari L, Toppari J, Reeve MP, Kero J.   +7 more
europepmc   +1 more source

Insulin receptor tyrosine kinase substrate links theE. coliO157:H7 actin assembly effectors Tir and EspF_Uduring pedestal formation

, 2009
Didier Vingadassalom, Arūnas Kazlauskas, Brian Skehan, Hui‐Chun Cheng, Loranne Magoun, Douglas R. Robbins, Michael K. Rosen, Kalle Saksela, John M. Leong   +8 more
openalex   +1 more source

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.

Journal of Clinical Investigation, 2013
C. Riehle, A. Wende, S. Sena, K. Pires, R. Pereira, Yi Zhu, H. Bugger, Deborah U. Frank, Jack Bevins, Dong Chen, C. N. Perry, X. Dong, Steven E Valdez, Monika Rech, X. Sheng, B. Weimer, R. Gottlieb, M. White, E. D. Abel   +18 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells. [PDF]

World J Diabetes
Li HY, Wang Y, Ran M, Gao F, Zhu BY, Xiao HY, Xu C.   +6 more
europepmc   +1 more source

Insulin receptor substrate-1 and dishevelled 2 are negatively regulated by microRNA-144 and inhibit nasopharyngeal carcinoma cell malignancy. [PDF]

Exp Ther Med, 2021
An X, Jiang Y, Chen D, Chen J.
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Insulin Receptor Substrate-2 Regulates the Secretion of Growth Factors in Response to Amino Acid Deprivation. [PDF]

Int J Mol Sci
Takahashi A, Furuta H, Nishi H, Kamei H, Takahashi SI, Hakuno F.   +5 more
europepmc   +1 more source

Compartmentalization and Insulin-Induced Translocations of Insulin Receptor Substrates, Phosphatidylinositol 3-Kinase, and Protein Kinase B in Rat Liver [PDF]

, 2000
A. Balbis
openalex   +1 more source