Results 241 to 250 of about 399,223 (393)

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Uncovering the function of insulin receptor substrate in termites' immunity through active immunization. [PDF]

J Insect Sci
Zhou W, Zhao X, Hassan A, Jia B, Liu L, Huang Q.   +5 more
europepmc   +1 more source

Thyroid-Stimulating Hormone Inhibits Insulin Receptor Substrate-1 Expression and Tyrosyl Phosphorylation in 3T3-L1 Adipocytes by Increasing NF-κB DNA-Binding Activity. [PDF]

Dis Markers, 2022
Zhang Y, Feng L.
europepmc   +1 more source

Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes [PDF]

, 1996
Danqun Guo, David B. Donner
openalex   +1 more source

Accelerated Atherosclerosis in Apoe−/− Mice Heterozygous for the Insulin Receptor and the Insulin Receptor Substrate-1

Arteriosclerosis, Thrombosis and Vascular Biology, 2012
E. Galkina, M. Butcher, S. Keller, M. Goff, Anthony C Bruce, H. Pei, I. Sarembock, J. Sanders, Melissa H. Nagelin, S. Srinivasan, R. Kulkarni, C. Hedrick, F. Lattanzio, A. Dobrian, J. Nadler, K. Ley   +15 more
semanticscholar   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Insulin receptor substrate family member IST-1 regulates the development of <i>Caenorhabditis elegans</i> <i>age-1</i> and <i>aap-1</i> mutants. [PDF]

MicroPubl Biol
Guerrero-Gómez D, Cabello J, Miranda-Vizuete A.   +2 more
europepmc   +1 more source

Relationship Between Insulin-Receptor Substrate 1 and Langerhans' Islet in a Rat Model of Type 2 Diabetes Mellitus. [PDF]

In Vivo, 2021
Atmodjo WL, Larasati YO, Jo J, Nufika R, Naomi S, Winoto I.   +5 more
europepmc   +1 more source

Insulin stimulated protein phosphorylation in human plasma liver membranes: Detection of endogenous or plasma membrane associated substrates for insulin receptor kinase

, 1987
JoséF. Caro, Jules A. Shafer, Simeon I. Taylor, S Raju, Nichola Perrotti, Madhur K. Sinha   +5 more
openalex   +2 more sources

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source