Results 261 to 270 of about 399,223 (393)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Disruption of insulin receptor substrate 2 (IRS2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster. [PDF]

Sci Rep
Hirose M, Inoue K, Matoba S, Tatebe T, Tokita S, Dodo Y, Tomishima T, Hasegawa A, Honda A, Ozaki M, Shinogi A, Yanagisawa R, Fauzi M, Murakami T, Inagaki N, Tamura M, Ogura A.   +16 more
europepmc   +1 more source

Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761. [PDF]

Bioengineered, 2022
Xu L, Tan Y, Xu F, Zhang Y.
europepmc   +1 more source

Insulin receptor substrate 1 (IRS1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

microRNA-141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2.

, 2016
Su Dong, Xianying Meng, Shuai Xue, Zewen Yan, Peiyou Ren, Jia Liu   +5 more
openalex   +1 more source

Substrate-Bound Insulin-Like Growth Factor (IGF)-I-IGF Binding Protein-Vitronectin-Stimulated Breast Cell Migration Is Enhanced by Coactivation of the Phosphatidylinositide 3-Kinase/AKT Pathway by αv-Integrins and the IGF-I Receptor [PDF]

, 2007
Brett G. Hollier, Jennifer Kricker, Derek R. Van Lonkhuyzen, David I. Leavesley, Zee Upton   +4 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Expression of Concern. Marco A. Carvalho-Filho, Mirian Ueno, Sandro M. Hirabara, Amedea B. Seabra, José B.C. Carvalheira, Marcelo G. de Oliveira, Lício A. Velloso, Rui Curi, and Mario J.A. Saad. S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt: A Novel Mechanism of Insulin Resistance. Diabetes 2005;54:959-967. DOI: 10.2337/diabetes.54.4.959. PMID: 15793233. [PDF]

Diabetes, 2023
American Diabetes Association.
europepmc   +1 more source

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.

Kidney International, 2011
A. Mima, Y. Ohshiro, Munehiro Kitada, M. Matsumoto, P. Geraldes, Chenzhong Li, Qian Li, G. White, C. Cahill, C. Rask-Madsen, G. King   +10 more
semanticscholar   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source