Results 281 to 290 of about 399,223 (393)

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells

, 2017
Jose Mercado-Matos, Jennifer L. Clark, Andrew J. Piper-Valillo, Jenny Janusis, Pilhan Kim   +4 more
openalex   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. [PDF]

Dis Markers, 2020
Gao C, Zhang H, Zhang WS, Fang L.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Insulin-stimulated Interaction between Insulin Receptor Substrate 1 and p85α and Activation of Protein Kinase B/Akt Require Rab5 [PDF]

, 2006
Xiong Su, Irfan J. Lodhi, Alan R. Saltiel, Philip D. Stahl   +3 more
openalex   +1 more source

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Journal of Neuroscience, 2003
M. Schubert, D. Brazil, D. Burks, J. Kushner, Jing Ye, C. L. Flint, Janet Farhang-Fallah, P. Dikkes, X. Warot, C. Río, G. Corfas, M. White   +11 more
semanticscholar   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

The hypothalamic-pituitary-thyroid axis is intact in male insulin receptor substrate 4 knockout mice. [PDF]

Eur Thyroid J
Brûlé E, Zhou X, Wang Y, Buddle ERS, Ongaro L, Loka M, Boelen A, Bernard D.   +7 more
europepmc   +1 more source

Expression of Concern. Henrique G. Zecchin, Fernanda B.M. Priviero, Claudio T. Souza, Karina G. Zecchin, Patrícia O. Prada, José B.C. Carvalheira, Licio A. Velloso, Edson Antunes, and Mario J.A. Saad. Defective Insulin and Acetylcholine Induction of Endothelial Cell-Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats. Diabetes 2007;56:1014-1024. DOI: 10.2337/db05-1147. PMID: 17229938. [PDF]

Diabetes, 2023
American Diabetes Association.
europepmc   +1 more source

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Diabetes, 2000
N. Kubota, K. Tobe, Y. Terauchi, K. Eto, T. Yamauchi, Reiko Suzuki, Y. Tsubamoto, K. Komeda, R. Nakano, H. Miki, S. Satoh, H. Sekihara, S. Sciacchitano, M. Lesniak, S. Aizawa, R. Nagai, S. Kimura, Y. Akanuma, S. Taylor, T. Kadowaki   +19 more
semanticscholar   +1 more source