Results 21 to 30 of about 399,223 (393)

Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes

Haematologica, 2012
Background In normal platelets, insulin inhibits agonist-induced Ca2+ mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca2+ mobilization, aggregation and procoagulant activity. We
Anja J. Gerrits, Eelo Gitz, Cornelis A. Koekman, Frank L. Visseren, Timon W. van Haeften, Jan Willem N. Akkerman   +5 more
doaj   +1 more source

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor

Molecular Medicine Reports, 2009
Insulin receptor substrates (IRS)-5 and -6 are two recently identified members of the IRS family. We investigated their roles as insulin receptor substrates and compared them with Src-homology-2-containing (Shc) protein, a well-established substrate. Bioluminescence resonance energy transfer (BRET) experiments showed no interaction between the receptor
Soetkin, Versteyhe, Christophe, Blanquart, Cornelia, Hampe, Shaukat, Mahmood, Nevena, Christeff, Pierre, De Meyts, Steven G, Gray, Tarik, Issad   +7 more
openaire   +3 more sources

Caspase-mediated Cleavage of Insulin Receptor Substrate [PDF]

Journal of Biological Chemistry, 2004
Apoptosis is an important mechanism for maintaining tissue homeostasis. The efficient induction and execution of apoptosis are essential for cell clearance in specific developmental situations. Insulin-like growth factor (IGF)-I is a survival factor for epithelial cells in the mammary gland, and its withdrawal or inhibition leads to apoptosis.
Green, Kirsty A., Naylor, Matthew J., Lowe, Emma T., Wang, Pengbo, Marshman, Emma, Streuli, Charles H.   +5 more
openaire   +3 more sources

Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats

Brazilian Journal of Medical and Biological Research, 1997
Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1).
A.D. Sasse, E. Chen, C.R.O. Carvalho, J.A.R. Gontijo, S.L. Brenelli, M.J.A. Saad   +5 more
doaj   +1 more source

The Common Single Cause of Chronic Multi-Hormonal Resistance in Oxidative Stress

Antioxidants, 2022
In diseases with concomitant oxidative stress, chronic multi-hormonal resistances could be detected. The most conspicuous component of these resistances is insulin resistance, but also leptin, erythropoietin, acetylcholine, triiodothyronine and glucagon ...
István Wittmann
doaj   +1 more source

53BP2S, Interacting with Insulin Receptor Substrates, Modulates Insulin Signaling [PDF]

Journal of Biological Chemistry, 2007
It is well known that insulin receptor substrates (IRS) act as a mediator for signal transduction of insulin, insulin-like growth factors, and several cytokines. To identify proteins that interact with IRS and modulate IRS-mediated signals, we performed yeast two-hybrid screening with IRS-1 as bait.
Fumihiko, Hakuno, Shigekazu, Kurihara, Robert T, Watson, Jeffrey E, Pessin, Shin-Ichiro, Takahashi   +4 more
openaire   +2 more sources

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*

Journal of Biological Chemistry, 2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which
Chunli Yu, Yan Chen, G. Cline, Dongyan Zhang, Haihong Zong, Yanlin Wang, R. Bergeron, Jason K. Kim, S. Cushman, G. Cooney, Bronwyn A Atcheson, M. White, E. Kraegen, G. Shulman   +13 more
semanticscholar   +1 more source

Insulin receptor substrate 2 is required for testicular development. [PDF]

PLoS ONE, 2013
Insulin receptor substrate (IRS) proteins are key mediators of insulin and insulin-like growth factor (IGF) signalling. In mice, deletion of Irs1 is associated with profound growth retardation and increased longevity whereas Irs2-deficiency causes ...
Richard J Griffeth, Jose Carretero, Deborah J Burks   +2 more
doaj   +1 more source

Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1 [PDF]

Journal of Biological Chemistry, 1995
Insulin stimulation of 3T3-L1 adipocytes results in rapid activation of the insulin receptor tyrosine kinase followed by autophosphorylation of the receptor and phosphorylation of insulin receptor substrate 1 (IRS-1), its major substrate. The insulin receptor resides mostly at the cell surface of 3T3-L1 adipocytes under basal conditions, while about ...
Heller-Harrison, Robin A., Morin, Michelle, Czech, Michael P.   +2 more
openaire   +3 more sources