Results 291 to 300 of about 399,223 (393)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

, 2013
M. Isabel G. Roncero, Elvira Álvarez, Carlos Acosta‐Olivo, Carmen Sanz, Pedro A. Barrio, Verónica Hurtado-Carneiro, Deborah J. Burks, Enrique Blázquez   +7 more
openalex   +2 more sources

Role of insulin receptor substrate‐1 for diethylnitrosamine plus high‐fat diet‐induced hepatic tumorigenesis in mice [PDF]

, 2013
Khadbaatar Zolzaya, Akinobu Nakamura, Kazuki Tajima, Yasuo Terauchi   +3 more
openalex   +1 more source

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

Journal of Clinical Investigation, 1995
Laurie J. Goodyear, Francesco Giorgino, L. A. Sherman, Julie O. Carey, Robert J. Smith, G. Dohm   +5 more
semanticscholar   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. [PDF]

J Biol Chem, 2020
Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, Minami S.   +7 more
europepmc   +1 more source

MicroRNA‑766 inhibits papillary thyroid cancer progression by directly targeting insulin receptor substrate 2 and regulating the PI3K/Akt pathway

, 2018
Jianjie Zhao, Zhirong Li, Yi Chen, Shu Zhang, Lingji Guo, Bo Gao, Yan Jiang, Wuguo Tian, Shuai Hao, Xiaohua Zhang   +9 more
openalex   +2 more sources

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

Localisation and endocrine control of hyaluronan synthase (HAS) 2, HAS3 and CD44 expression in sheep granulosa cells [PDF]

, 2016
A. A. Fouladi-Nashta, Adamia, Allegrucci, Baerwald, Bodevin-Authelet, Camenisch, Campbell, Campbell, Deroo, El Maradny, Erickson, Fortune, Freudenberger, G. M. Hartshorne, Galluzzo, Hall, Hettinger, Hunter, Itano, Itano, Itano, Jacob, Jain, Juengel, Koehler, Kosaki, Kultti, Laurent, Lee, Luo, Manna, Marei, Marei, Marzioni, Miyake, Miyake, Moriarty, Necas, Nykopp, Nykopp, Ohta, Ohta, Perry, Perry, Pettersson, R. Chavoshinejad, Raheem, Rilla, Robinson, Sainio, Saito, Scaramuzzi, Schoenfelder, Silva, Stern, Tempel, Tienthai, Toole, Toole, Toole, Tsonis, Ulbrich, W. F. A. Marei, Watson, Weigel, Zhao   +65 more
core   +1 more source