Results 311 to 320 of about 399,223 (393)

Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.

Endocrinology, 2009
T. Wada, Satoshi Ohshima, E. Fujisawa, D. Koya, H. Tsuneki, T. Sasaoka   +5 more
semanticscholar   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. [PDF]

World J Gastroenterol, 2020
Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M.   +7 more
europepmc   +1 more source

A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression

, 2017
Jose Mercado-Matos
openalex   +1 more source

EXERCISE EFFECTS ON MUSCLE GLUCOSE UPTAKE AND INSULIN ACTION [PDF]

, 2008
Derave, Wim
core   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Insulin receptor substrate‐1 time‐dependently regulates bone formation by controlling collagen Iα2 expression via miR‐342

, 2016
Yue Guo, Chen‐Yi Tang, Xiaofei Man, Haoneng Tang, Jun Tang, Fang Wang, Ci‐La Zhou, Shuwen Tan, Yun‐Zhi Feng, Hou‐De Zhou   +9 more
openalex   +1 more source

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

Molecular and Cellular Biology, 2009
A. Assmann, K. Ueki, J. Winnay, T. Kadowaki, R. Kulkarni   +4 more
semanticscholar   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

Molecular Endocrinology, 2000
T. Haruta, T. Uno, J. Kawahara, A. Takano, K. Egawa, Prem M. Sharma, J. Olefsky, J. Olefsky, M. Kobayashi   +8 more
semanticscholar   +1 more source