Results 341 to 350 of about 399,223 (393)

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

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Insulin Receptor Substrate (IRS-1)

2016
Insulin receptor substrate (IRS-1) is an adapter signalling protein which lacks intrinsic kinase activity. IRS-1 was isolated as an insulin receptor substrate but over time various studies have shown that it is capable of working in a range of growth hormone and cytokine receptor signalling cascades.
A. Salajegheh
openaire   +2 more sources

Substrates for Insulin-Receptor Kinase

Diabetes Care, 1990
Several studies suggest that the tyrosine-specific protein kinase activity of the β-subunit of the insulin receptor is necessary to mediate the biological effects of insulin. This conclusion leads to the hypothesis that the effect of insulin is mediated through the tyrosine phosphorylation of cellular substrates by the insulin-receptor tyrosine kinase.
M, Kasuga, T, Izumi, K, Tobe, T, Shiba, K, Momomura, Y, Tashiro-Hashimoto, T, Kadowaki   +6 more
openaire   +2 more sources

Insulin receptor substrate proteins and diabetes

Archives of Pharmacal Research, 2004
The discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors to the intracellular signaling cascades is a key step to understanding insulin and insulin-like growth factor (IGF) action. Moreover, IRS-proteins coordinate signals from the insulin and IGF receptor tyrosine kinases with those generated by ...
Yong Hee, Lee, Morris F, White
openaire   +2 more sources

Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

Biochemical Pharmacology, 2023
The number of people with diabetes worldwide is increasing annually, resulting in a serious economic burden. Insulin resistance is a major pathology in the early onset of diabetes mellitus, and therefore, related drug studies have attracted research attention.
Jingqian Su, Lu Tang, Yingsheng Luo, Jingran Xu, Songying Ouyang   +4 more
openaire   +2 more sources

Insulin signalling: the role of insulin receptor substrate 1

Trends in Cell Biology, 1994
The insulin receptor is a ligand-activated tyrosine kinase that phosphorylates its major substrate protein, insulin receptor substrate 1 (IRS1), at multiple sites. Tyrosine-phosphorylated IRS1 then serves as a docking/effector protein for at least four Src homology 2 (SH2)-domain proteins involved in signal transduction. This initial step in signalling
S R, Keller, G E, Lienhard
openaire   +2 more sources

Insulin receptor and insulin receptor substrate‐1 in rat retinae

Clinical & Experimental Ophthalmology, 2000
ABSTRACTInsulin receptor substrate‐1 (IRS‐1) is a major cytosolic substrate of the insulin receptor. Expression of insulin receptor and IRS‐1, and the distribution of these components of the insulin‐signalling pathway, were investigated in rat retinae. Insulin receptor and IRS‐1 were located in retinal sections with anti‐insulin receptor and anti‐IRS‐1
AD Gosbell, I Favilla, KM Baxter, P Jablonski   +3 more
openaire   +1 more source