Results 351 to 360 of about 399,223 (393)

New frontiers in insulin receptor substrate signaling

Trends in Endocrinology & Metabolism, 1995
Although most tyrosine kinase growth factor receptors directly bind Src homology 2 (SH2) proteins, the insulin receptor, and a select group of other hormone receptors-including an emerging group of cytokine receptors-phosphorylate intracellular insulin receptor substrate (IRS) proteins, which subsequently bind SH2 proteins.
M G, Myers, M F, White
openaire   +2 more sources

Insulin Resistance and Growth Retardation in Mice Lacking Insulin Receptor Substrate‐1 and Identification of Insulin Receptor Substrate‐2

Diabetic Medicine, 1996
To clarify the physiological roles of insulin receptor substrate‐1 (IRS‐1) in vivo, we made mice with a targeted disruption of the IRS‐1 gene locus. Mice homozygous for targeted disruption of the IRS‐1 gene were born alive but were retarded in embryonal and postnatal growth.
T, Kadowaki, H, Tamemoto, K, Tobe, Y, Terauchi, K, Ueki, Y, Kaburagi, T, Yamauchi, S, Satoh, H, Sekihara, S, Aizawa, Y, Yazaki   +10 more
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Association of insulin receptor substrate-1 with integrins

Science, 1994
Insulin stimulation was found to promote association of the alpha v beta 3 integrin (a vitronectin receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates insulin signaling by binding other signaling molecules, including growth factor receptor-bound protein 2 (Grb2) and phosphatidylinositol-3' kinase. Insulin-treated
K, Vuori, E, Ruoslahti
openaire   +2 more sources

Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase

Clinical Cancer Research, 2011
Abstract Insulin receptor substrates (IRS) serve as downstream messengers from activated cell surface receptors to numerous signaling pathway cascades. One of these pathways, phosphoinositide 3-kinase (PI3K), frequently displays aberrant function in the setting of cancer.
Heather E, Metz, A McGarry, Houghton
openaire   +2 more sources

Cytosolic Substrates for the Insulin Receptor Kinase

1988
Insulin receptor belongs to a family of cell surface receptors possessing ligand-activated tyrosine kinase activity. In the case of the insulin receptor, phosphorylation of tyrosine residues in its β subunit is stimulated by the binding of insulin to the ∝subunit (1–8), resulting in an increased receptor tyrosine phosphotransferase activity towards ...
Y C, Kwok, C C, Yip
openaire   +2 more sources

Insulin and IGF‐I signaling through the insulin receptor substrate 1

Molecular Reproduction and Development, 1993
AbstractThe insulin and insulin‐like growth factor‐I (IGF‐I) receptors are tyrosine kinases. Consequently, an approach to investigating signaling pathways from these receptors is to characterize proteins rapidly phosphorylated on tyrosine in response to insulin and IGF‐I. In many cell types the most prominent phosphotyrosine (Ptyr) protein, in addition
S R, Keller, L, Lamphere, B E, Lavan, M R, Kuhné, G E, Lienhard   +4 more
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Insulin receptor substrate proteins and neuroendocrine function

Biochemical Society Transactions, 2001
A family of insulin receptor substrate (IRS) proteins mediates the pleiotropic effects of insulin and insulin-like growth factor 1 (IGF-1) on cellular function by recruiting several intracellular signalling networks. Conventional murine knockout strategies have started to reveal distinct physiological roles for the IRS proteins.
openaire   +2 more sources

Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells

Diabetes, 1996
The expression of insulin receptor mRNA was examined in rat pancreatic islet cells by single-cell reverse transcriptase (RT)–polymerase chain reaction (PCR). Single cells from disaggregated islets were individually isolated in a microcapillary pipet, and the β-cells were identified by amplification of the mRNA for insulin.
M C, Harbeck, D C, Louie, J, Howland, B A, Wolf, P L, Rothenberg   +4 more
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Nuclear translocation of insulin receptor substrate‐1 by the insulin receptor in mouse embryo fibroblasts

Journal of Cellular Physiology, 2003
AbstractTranslocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in mouse embryo fibroblasts (MEF), that do not express the ...
A. WU, SCIACCA, LAURA, R. BASERGA
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Insulin receptor and insulin receptor substrate-I in rat retinae.

Clinical & experimental ophthalmology, 2000
Insulin receptor substrate-I (IRS-I) is a major cytosolic substrate of the insulin receptor Expression of insulin receptor and IRS-I, and the distribution of these components of the insulin-signalling pathway, were investigated in rat retinae. Insulin receptor and IRS-I were located in retinal sections with anti-insulin receptor and anti-IRS-I ...
A D, Gosbell, I, Favilla, K M, Baxter, P, Jablonski   +3 more
openaire   +1 more source