Results 51 to 60 of about 399,223 (393)

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation*

Journal of Biological Chemistry, 2014
Background: Metabolic stresses, including hyperinsulinemia, promote insulin resistance. Results: Monoclonal antibodies raised against Ser(P)/Thr(P) residues in IRS1 were used to quantify phosphorylation in response to insulin or agents that model ...
Nancy J Hançer, W. Qiu, Christine E. Cherella, Yedan Li, Kyle D. Copps, M. White   +5 more
semanticscholar   +1 more source

The effect of various intake levels of soybean oil on blood glucose and inflammation in mice

Food and Agricultural Immunology, 2018
The effects of various intake levels of soybean oil on carbohydrate metabolism and inflammation in mice were studied. Mice were supplied with different diets, in which soybean oil provided 5, 10, 15, 20, 25, and 30% of total energy. Blood glucose indices,
Xinli Pei, Zhongguo Xie, Jing Wang, Kaiwen Shi, Fei Han, Aike Li, Haiying Liu   +6 more
doaj   +1 more source

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 *

Journal of Biological Chemistry, 2000
Tumor necrosis factor α (TNFα) inhibits insulin action, in part, through serine phosphorylation of IRS proteins; however, the phosphorylation sites that mediate the inhibition are unknown.
Vincent Aguirre, T. Uchida, L. Yenush, R. Davis, M. White   +4 more
semanticscholar   +1 more source

Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Journal of Aging Research, 2017
Vasohibin-1 (Vash1), originally isolated as an endothelium-derived angiogenesis inhibitor, has a characteristic of promoting stress tolerance in endothelial cells (ECs).
Eichi Takeda, Yasuhiro Suzuki, Tetsuya Yamada, Hideki Katagiri, Yasufumi Sato   +4 more
doaj   +1 more source

Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells [PDF]

, 2004
Because beta-catenin target genes such as cyclin D1 are involved in cell cycle progression, we examined whether beta-catenin has a more pervasive role in normal cell proliferation, even upon stimulation by non-Wnt ligands.
Asthagiri, Anand R., Graham, Nicholas A.
core   +1 more source

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210

Journal of Biological Chemistry, 2002
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin resistance may involve the phosphorylation of serine residues in insulin receptor substrate-1 (IRS-1), leading to impairment in
Zhanguo Gao, D. Hwang, Fredly Bataille, M. Lefevre, D. York, M. Quon, Jianping Ye   +6 more
semanticscholar   +1 more source

Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. [PDF]

PLoS ONE, 2011
Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of insulin signaling and energy balance, but its role in brown fat adipogenesis requires additional investigation.To precisely determine the role of PTP1B in adipogenesis, we ...
Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata, Izumi Matsuo, Heike Keilhack, Fawaz G Haj   +5 more
doaj   +1 more source

Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Food Science and Human Wellness, 2023
Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone ...
Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao   +12 more
doaj   +1 more source

Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in ...
Hongzhou Liu, Nan Li, Mengmeng Jin, Xinyu Miao, Xinjie Zhang, Wenwen Zhong   +5 more
doaj   +1 more source

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins [PDF]

Journal of Biological Chemistry, 1999
Insulin receptor substrates (IRS) mediate biological actions of insulin, growth factors, and cytokines. All four mammalian IRS proteins contain pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains at their N termini. However, the molecules diverge in their C-terminal sequences.
P, Xu, A R, Jacobs, S I, Taylor
openaire   +2 more sources