Results 221 to 230 of about 805,287 (382)

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Advanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah   +7 more
wiley   +1 more source

Insulin resistance is an important determinant of left ventricular mass in the obese. [PDF]

, 1993
Zion Sasson, Yosef Rasooly, T. Bhesania, Iris Rasooly   +3 more
openalex   +1 more source

4D Biofabrication of Magnetically Augmented Callus Assembloid Implants Enables Rapid Endochondral Ossification via Activation of Mechanosensitive Pathways

Advanced Science, EarlyView.
Magnetically augmented biohybrid cartilaginous microtissues enable remote microtissue motion control and assembly as well as targeted differentiation. This study demonstrates accelerated endochondral ossification under magnetic stimulation, highlighting cartilaginous assembloid constructs’ ability to retain long‐term magnetic properties.
Konstantinos Ioannidis, Andreas Dimopoulos, Isaak Decoene, Maya Guilliams, Hanna Svitina, Liudmyla Storozhuk, Rodrigo de Oliveira‐Silva, Sergey Basov, Nguyen Thi Kim Thanh, Stefanos Mourdikoudis, Margriet J. Van Bael, Bart Smeets, Dimitrios Sakellariou, Ioannis Papantoniou   +13 more
wiley   +1 more source

Insulin Resistance and Cancer. [PDF]

J Diabetes
Bloomgarden Z.
europepmc   +1 more source

Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance. [PDF]

, 1994
Pierre Maheux, Jørgen Jeppesen, Wayne Huey‐Herng Sheu, C.B. Hollenbeck, Cynthia Clinkingbeard, Michael S. Greenfield, Y D Chen, Gerald M. Reaven   +7 more
openalex   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

Advanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang, Xinyuan Yang, Chong Wang, Luoran Shang   +3 more
wiley   +1 more source

Is Insulin Resistance an Independent Predictor of Atherosclerosis? [PDF]

J Clin Med
Landowska M, Kałuża B, Watała C, Babula E, Żuk-Łapan A, Woźniak K, Kargul A, Jurek J, Korcz T, Cicha-Brzezińska M, Franek E.   +10 more
europepmc   +1 more source

Insulin resistance, insulin, proinsulin, and ambulatory blood pressure in type II diabetes. [PDF]

, 1994
Jonathan Pinkney, Vidya Mohamed‐Ali, A. E. Denver, C Foster, Mike Sampson, John Yudkin   +5 more
openalex   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source