Results 291 to 300 of about 3,853,066 (390)

Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis‐Associated Colorectal Cancer

Advanced Science, Volume 12, Issue 11, March 20, 2025.
In the ulcerative colitis to colitis‐associated colorectal cancer transition, metabolic changes vary at specific disease stages. Normal adjacent tissue is metabolically distinct from both normal and tumor tissues. Eicosapentaenoic acid is a key metabolite exerting anti‐inflammatory and anti‐cancer effects by inhibiting insulin‐like growth factor ...
Ruiqi Sun, Yuanyuan Zhang, Xian Zhao, Tian Tang, Yuepeng Cao, Liu Yang, Yuan Tian, Zunjian Zhang, Pei Zhang, Fengguo Xu   +9 more
wiley   +1 more source

Comparison of triglyceride glucose index and other insulin resistance indexes in children with overweight and obesity. [PDF]

BMC Endocr Disord
Kalyoncu D, Kavrak Kursun M.
europepmc   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Correspondence: insulin resistance and chronic kidney disease in patients without diabetes. [PDF]

BMC Nephrol
Pham HT, Truong-Nguyen KH, Tran MH.
europepmc   +1 more source

The Role of β₂-Adrenoceptor on the Pathogenesis of Insulin Resistance in Essential Hypertension

, 1994
Jinchi KIM, S Shigetomi, Kiyonobu TANAKA, Zen-o Yamada, Shigeatsu Hashimoto, S Fukuchi   +5 more
openalex   +2 more sources

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Selenoprotein P1 as a biomarker of insulin resistance in pediatric obesity: Insights and implications.

World J Clin Pediatr
Cheng CH, Hao WR, Cheng TH.
europepmc   +1 more source

The role of immunity in insulin resistance in patients with polycystic ovary syndrome. [PDF]

Front Endocrinol (Lausanne)
Zhang Q, Yang Z, Ou X, Zhang M, Qin X, Wu G.   +5 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source