Results 291 to 300 of about 4,469,131 (358)
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, EarlyView.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source
Role and interaction of LncRNAs and insulin resistance in polycystic ovary syndrome: a narrative review. [PDF]
J Ovarian ResPeng M, Zhang X, Yang X, Ye T, Liu B.
europepmc +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Adipose Tissue Insulin Resistance: A Key Driver of Metabolic Syndrome Pathogenesis. [PDF]
BiomedicinesRabiee A, Hossain MA, Poojari A.
europepmc +1 more source
Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture
Advanced Science, EarlyView.Matrigel remains the most widely used scaffold in organoid and 3D culture despite its murine origin, variability, and translational limitations. This review discusses the barriers to replacing Matrigel with xeno‐free alternatives and introduces practical tools, including a matrix selection checklist and scaffold assessment criteria, to guide the ...
Lisa Wolff, Sven Hendrix
wiley +1 more source
Relation Between Inflammatory Parameters and Insulin Resistance Indices in Cows During Early Lactation. [PDF]
MetabolitesCincović M +6 more
europepmc +1 more source
Advanced Science, EarlyView.Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang +13 more
wiley +1 more source
Establishment and Evaluation of HepG2 Cell Insulin Resistance Model. [PDF]
Diabetes Metab Syndr ObesMeng Z +5 more
europepmc +1 more source