Results 51 to 60 of about 797,794 (382)
Update on the genetic and epigenetic etiology of gestational diabetes mellitus: a review [PDF]
arXiv, 2021 Background: Many studies have been conducted on the genetic and epigenetic etiology of gestational diabetes mellitus (GDM) in the last two decades because of the diseases increasing prevalence and role in the global diabetes mellitus (DM) explosion. An update on the genetic and epigenetic etiology of GDM then becomes imperative to better understand and
arxiv
Insulin Resistance and Atherosclerosis [PDF]
Endocrine Reviews, 2006 The epidemic of obesity in the developed world over the last two decades is driving a large increase in type 2 diabetes and consequentially setting the scene for an impending wave of cardiovascular morbidity and mortality. It is only now being recognized that the major antecedent of type 2 diabetes, insulin resistance with its attendant syndrome, is ...
Anthony M. Dart +4 more
openaire +4 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The Pecularities of Correlation Between Insulin Resistance, Carbohydrate and Lipid Metabolism Indices in Patients with Graves'disease [PDF]
, 2017 Aim. The number of patients with endocrine disorders in the world, in particular, Graves' disease is continuously increasing. Recent studies have determined the fact of insulin resistance in thyroid disorders.
Kikhtyak, O. (Olesya) +2 more
core +2 more sources
Impairment of insulin-stimulated glucose utilization is associated with burn-induced insulin resistance in mouse muscle by hyperinsulinemic-isoglycemic clamp [PDF]
arXiv, 2020 Burn-induced insulin resistance is associated with increased morbidity and mortality; however, the impact of burn injury on tissue-specific insulin sensitivity and its molecular mechanisms with consideration of insulin state remains unknown in rodent models.
arxiv
Inflammation and insulin resistance [PDF]
FEBS Letters, 2007 Obesity‐induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro‐inflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin ...
Jerrold M. Olefsky, Carl de Luca
openaire +3 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Frontiers in Endocrinology, 2022 The pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and ...
Peng-Fei Ding +11 more
doaj +1 more source
The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation In Insulin-Resistant Rat Adipocytes In Vitro [PDF]
, 1993 Sulfonylurea drugs are widely used in the therapy of NIDDM. The improvement of glucose tolerance after long-term treatment of NIDDM patients with the drug can be explained by stimulation of glucose utilization in peripheral tissues that are characterized
Müller, Günter, Wied, Susanne
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source