Results 71 to 80 of about 861,807 (357)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Insulin resistance causes inflammation in adipose tissue [PDF]

, 2018
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation.
Anne Christin Meyer-Gerspach, Bettina Woelnerhanssen, Cho, Christoph Beglinger, Diana Weissenberger, Gene Ontology, Irina C. Frei, Jerome A. Meier, Marco Colombi, Marta M. Swierczynska, Michael N. Hall, Mitsugu Shimobayashi, Morley, Nicolas Clement, Ofei, Paquot, Paul Jenö, Ralph Peterli, Rosen, Suzette Moes, Tang, Verena Albert, Wascher   +22 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Insulin Resistance and Hypertension [PDF]

Hypertension, 2004
The association between insulin resistance and insulinemia and hypertension is controversial. We examined the relation between insulin resistance and hypertension in 564 non-Hispanic whites (NHW), 505 Hispanics (H), and 413 African Americans (AA) who participated in the Insulin Resistance Atherosclerosis Study (IRAS).
Marian Rewers, Richard N. Bergman, Joseph V. Selby, Peter J. Savage, George Howard, Salwa Fahmi, Sujata Jinagouda, Mohammed F. Saad, Dan Zaccaro, Steven M. Haffner   +9 more
openaire   +3 more sources

Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats [PDF]

, 2014
Chronic psychological stress is a prominent risk factor involved in the pathogenesis of many complex diseases, including major depression, obesity, and type II diabetes.
Abel, Adler, Ahima, Archuleta, Barsy, Bartness, Bartolomucci, Bartolomucci, Bjorntorp, Bose, Bost, Bradesi, Bray, Buren, Cai, Christiansen, Depke, Despres, Desreumaux, Edgar, Fortuno, Gonnissen, Griffin, Hawley, Hennings, Hirosumi, Hotamisligil, Hotamisligil, Hotamisligil, Karagiannides, Karagiannides, Kim, Kyrou, Lamounier-Zepter, Lehrke, Ma, Marra, Morino, Nieuwenhuizen, Ogden, Pechlivanova, Perrini, Razzouk, Rodriguez, Shively, Slentz, Speaker, Stubbs, Tanti, van Reedt Dortland, Willner, Yu, Yuan, Zhang   +53 more
core   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

eLife, 2018
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue.
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James   +23 more
doaj   +1 more source

Analysis of the effect of hashimoto's thyroiditis and insulin resistance on ovarian volume in patients with polycystic ovary syndrome

BMC Women's Health, 2023
Objective In this study, patients were divided into two groups. Patients with polycystic ovary syndrome (PCOS) and patients with polycystic ovary syndrome + Hashimoto's Thyroid (PCOS + HT).
Gülcan Gencer, Aliye Nigar Serin, Kerem Gencer   +2 more
doaj   +1 more source

Sphingolipid metabolism in brain insulin resistance and neurological diseases

Frontiers in Endocrinology, 2023
Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence,
Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang Li   +4 more
doaj   +1 more source

Inflammation and Insulin Resistance [PDF]

Diabetes Care, 2003
This Is the second of two articles describing a symposium on the relationship between inflammation and insulin resistance that was held in Niagra Falls, NY, 20–21 September 2002. Antonio Ceriello (Udine, Italy) discussed the role of glucose intake and postprandial hyperglycemia in the development of diabetes complications, as well as the relationship ...
openaire   +5 more sources