Results 111 to 120 of about 458,144 (260)

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

A Case of Fulminant Type 1 Diabetes With Residual Insulin Secretion. [PDF]

Cureus
Kato T, Harada N, Nishikawa Y, Yamamoto K, Murakami T, Ueda Y, Okamoto M, Yabe D.   +7 more
europepmc   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice. [PDF]

Diabetes
Basu L, Grieco-St-Pierre L, Ching MEA, Stead JDH, Hanson AA, Palaniyandi J, van Zyl E, Hoyeck MP, McKay KS, van Allen KA, Lee H, Dai XQ, Bautista A, Fadzeyeva E, Mulvihill EE, Yauk CL, Mennigen JA, MacDonald PE, Bruin JE.   +18 more
europepmc   +1 more source

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

Subcellular Compartmentalization of Glucose Mediated Insulin Secretion. [PDF]

Cells
Wang Z, Gurlo T, Satin LS, Fraser SE, Butler PC.   +4 more
europepmc   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Low-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion. [PDF]

J Mol Cell Biol
Xiong FR, Zhu JJ, Zhu XR, Lu J, Yang JK.
europepmc   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source