Results 261 to 270 of about 523,944 (309)

Somatostatin and insulin secretion

Metabolism, 1978
Abstract The inhibitory effect of somatostatin was first demonstrated in in vitro studies in rat pituitary cell cultures. Thus, initially, its action on the release of pituitary hormones in man and animals was the main focus of interest. While investigating the effect of somatostatin on growth hormone release we, as well as other groups, made the ...
S, Efendic, P E, Lins, R, Luft
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Insulin Secretion in Obesity

New England Journal of Medicine, 1967
ALTHOUGH hyperinsulinemia has been well established in obese subjects1 , 2 only some demonstrate abnormalities of glucose tolerance. It has been suggested that the ability of the obese subject to maintain normal glucose tolerance is a function of B-cell reserve, implying that insulin secretory rates and plasma insulin levels would be higher in obese ...
R A, Kreisberg, B R, Boshell, J, DiPlacido, R F, Roddam   +3 more
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Ovarian tumors secreting insulin

Endocrine, 2015
Combined ovarian germ cell and neuroendocrine tumors are rare. Only few cases of hyperinsulinism due to ovarian ectopic secretion have been hypothesized in the literature. An ovarian tumor was diagnosed in a 76-year-old woman, referred to our department for recurrent hypoglycemia with hyperinsulinism.
BATTOCCHIO, MARIALBERTA, Zatelli, M. C., CHIARELLI, SILVIA, Trento, M., Ambrosio, M. R., PASQUALI, CLAUDIO, De Carlo, E., DASSIE, FRANCESCA, Mioni, R., Rebellato, A., FALLO, FRANCESCO, Degli Uberti, E., Martini, C., VETTOR, ROBERTO, Maffei, P.   +14 more
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Insulin secretion in hyperlipoproteinemias

Acta Diabetologica Latina, 1974
Insulin secretion has been evaluated after oral glucose loading and other stimuli (tolbutamide, glucagon, arginine and i.v. glucose) in a group of 3 patients with familial hyperchylomicronemia (Fredrickson’s Type I), 33 patients with primary hypercholesterolemia (Fredrickson’s Type II) and 89 patients with endogenous hypertriglyceridemia.
A. Tiengo, MUGGEO, Michele, D. Fedele, E. Marchiori, G. Crepaldi   +4 more
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Insulin Secretion in Acromegaly

The Journal of Clinical Endocrinology & Metabolism, 1970
ABSTRACT A comparative study of insulin release was made in 9 acromegalic and 39 normal subjects who had normal fasting plasma glucoses. Both hyperglycemic (increase of plasma glucose of at least 25 mg/100 ml) and nonhyperglycemic stimuli were used. Those producing hyperglycemia included a 100 g oral glucose tolerance test and a glucose-protein meal ...
S E, Fineberg, T J, Merimee, D, Rabinowitz, P J, Edgar   +3 more
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Extrapancreatic Insulin-Secreting Tumor

New England Journal of Medicine, 1964
DOEGE1 reported, in 1930, the first case of fibro-sarcoma associated with hypoglyccmia; however, it was not until 1942 that the specific syndrome of spontaneous hypoglycemia associated with tumors of mesodermal origin was clearly recognized.2 Since that time 39 new cases have been described.3 The location of the tumors has been almost equally ...
B R, BOSHELL, J J, KIRSCHENFELD, P S, SOTERES   +2 more
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Hypothermia and Insulin Secretion

Endocrinology, 1970
The effect of decreased body temperature on insulin secretion was studied using the isolated perfused rat pancreas. It was found that hypothermia directly inhibits insulin release and that there exists a direct relationship between tissue temperature and total quantity of insulin released (in response to either glucose or tolbutamide stimulation).
D L, Curry, K P, Curry
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SIK2 regulates insulin secretion

Nature Cell Biology, 2014
Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.
Bengt-Frederik, Belgardt, Markus, Stoffel   +1 more
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Inhibition of Insulin Secretion

2005
Reports of the effects of amylin and amylin agonists on insulin secretion have varied widely. Some confusion can be attributed to the use of human amylin, which has been shown to readily fall out of solution resulting in low estimates of bioactivity. Some confusion can be resolved by assessing the probability that this had happened. The view taken here,
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Neuroendocrine Control of Insulin Secretion

Diabetes, 1976
The effects of thyrotropin-releasing hormone, luteinizing hormone-releasing hormone, substance P, somatostatin, and a partially purified hypothalamic extract on insulin secretion were tested both in vitro and in vivo. Only somatostatin and the hypothalamic extract affected insulin secretion.
R B, Lockhart-Ewart, C, Mok, J M, Martin
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