Results 271 to 280 of about 543,808 (360)

First Korean Case of 5q35.2q35.3 Microduplication With Reversed Sotos Syndrome Phenotype and Growth Hormone Deficiency: Expanding the Endocrine Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Sotos syndrome is an overgrowth disorder caused by nuclear receptor binding SET domain protein 1 (NSD1) haploinsufficiency, whereas reciprocal 5q35.2q35.3 microduplication produces a reversed phenotype with growth retardation, microcephaly, delayed bone age, and neurodevelopmental delay.
Sejin Kim, Jung Sook Ha, Jun Chul Byun
wiley   +1 more source

Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine <i>in vitro</i>. [PDF]

Front Endocrinol (Lausanne)
Xing JJ, Li W, Chen C.
europepmc   +1 more source

Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans. [PDF]

, 1991
Atwater, I, Boschero, AC, Carroll, PB, Gonçalves, AA, Starzl, TE, Tzakis, AG   +5 more
core  

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations. [PDF]

Mol Metab
Ferreira SM, Hagan DW, Stis AE, Widener AE, Cuaycal AE, Rancourt C, Readey AG, Smurlick DS, Fu DA, Campbell-Thompson M, Rupnik MS, Phelps EA.   +11 more
europepmc   +1 more source

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

, 2009
Lynley D. Pound, Suparna A. Sarkar, Richard K.P. Benninger, Yingda Wang, Adisak Suwanichkul, Melanie K. Shadoan, Richard L. Printz, James K. Oeser, Catherine E. Lee, David W. Piston, Owen P. McGuinness, John C. Hutton, D.R. Powell, Richard M. O’Brien   +13 more
openalex   +2 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells. [PDF]

FEBS J
Yıldırım S, Mhamane A, Lösch S, Wieder A, Ermis E, König AC, Yilmaz S, Hauck SM, Kocabas F, Szendroedi J, Herzig S, Ekim B.   +11 more
europepmc   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes. [PDF]

BMJ Open Diabetes Res Care
Katayama A, Hasegawa M, Morimoto E, Watanabe M, Matsushita Y, Takeda M, Kai K, Yoshida M, Tsukahara S, Okimoto N, Tada K, Kumazawa K, Hida K.   +12 more
europepmc   +1 more source