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Biosynthesis and secretion of insulin
British Medical Bulletin, 1989The mechanisms involved in the biosynthesis, storage and secretion of insulin in the normal pancreatic B-cell have been the subject of intensive investigation during the last twenty years. As a result of this activity a relatively clear picture has emerged about the basic processes involved, and increasing information is available of their regulation ...
S L, Howell, G S, Bird
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Hypothermia and Insulin Secretion
Endocrinology, 1970The effect of decreased body temperature on insulin secretion was studied using the isolated perfused rat pancreas. It was found that hypothermia directly inhibits insulin release and that there exists a direct relationship between tissue temperature and total quantity of insulin released (in response to either glucose or tolbutamide stimulation).
D L, Curry, K P, Curry
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Metabolism, 1984
Recent advances in insulin secretion indicate that pertussis toxin abolishes the inhibition by alpha 2 adrenoceptor activation of insulin release by the pancreas. Pertussis toxin adenosine diphosphate (ADP) ribosylates an inhibitory guanine nucleotide-binding protein (Ni) involved in inhibition of adenylate cyclase.
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Recent advances in insulin secretion indicate that pertussis toxin abolishes the inhibition by alpha 2 adrenoceptor activation of insulin release by the pancreas. Pertussis toxin adenosine diphosphate (ADP) ribosylates an inhibitory guanine nucleotide-binding protein (Ni) involved in inhibition of adenylate cyclase.
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Multiscale Modeling of Insulin Secretion
IEEE Transactions on Biomedical Engineering, 2011Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale.
PEDERSEN, MORTEN GRAM +2 more
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Inhibition of Insulin Secretion
2005Reports of the effects of amylin and amylin agonists on insulin secretion have varied widely. Some confusion can be attributed to the use of human amylin, which has been shown to readily fall out of solution resulting in low estimates of bioactivity. Some confusion can be resolved by assessing the probability that this had happened. The view taken here,
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Mechanisms of Insulin Secretion
New England Journal of Medicine, 1970IN the bodily economy of animals, including man, insulin has evolved into the premier regulator of storage and conservation of the three major foodstuffs.
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Desensitization of insulin secretion
Biochemical Pharmacology, 2002Desensitization of insulin secretion describes a reversible state of decreased secretory responsiveness of the pancreatic beta-cell, induced by a prolonged exposure to a multitude of stimuli. These include the main physiological stimulator, glucose, but also other nutrients like free fatty acids and practically all pharmacological stimulators acting by
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Effects of Aging on Insulin Secretion
Diabetes, 1989Aging is associated with hyperinsulinemia, but reports vary on the contributions of altered insulin clearance versus insulin secretion to this phenomenon. To elucidate the role of insulin secretion in the hyperinsulinemia of aging, 10 elderly (age 66 ± 4 yr, body mass index 25 ± kg/m2) and 8 young (age 30 ± 5 yr, body mass index 24 ± 3 kg/m2) subjects ...
B, Gumbiner +5 more
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Neuroendocrine Control of Insulin Secretion
Diabetes, 1976The effects of thyrotropin-releasing hormone, luteinizing hormone-releasing hormone, substance P, somatostatin, and a partially purified hypothalamic extract on insulin secretion were tested both in vitro and in vivo. Only somatostatin and the hypothalamic extract affected insulin secretion.
R B, Lockhart-Ewart, C, Mok, J M, Martin
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Colchicine and Insulin Secretion in Man
Diabetes, 1981The present study is aimed at investigating the effect of acute and chronic colchicine administration on insulin secretion in humans. Acute insulin response to glucose (0.33 g/kg) was significantly decreased by colchicine (3 mg i.v.). In fact, this response (mean change 2–10 min insulin) was 44 ± 8 μU/ml before and 32 ± 6 μU/ml after colchicine ...
GIUGLIANO, Dario +6 more
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