Results 101 to 110 of about 427,560 (316)

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Adding pioglitazone to insulin containing regimens in type 2 diabetes : systematic review and meta-analysis [PDF]

, 2009
Background Type 2 diabetes is treated in a stepwise manner, progressing from diet and physical activity to oral antidiabetic agents and insulin. The oral agent pioglitazone is licensed for use with insulin when metformin is contraindicated or not ...
Waugh Norman, Christine Clar, Clar Christine, Waugh, Norman, Norman Waugh, Royle Pamela, Clar, C., Royle, Pamela, Pamela Royle   +8 more
core   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity

PPAR Research, 2009
PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity.
Anna Leonardini, Luigi Laviola, Sebastio Perrini, Annalisa Natalicchio, Francesco Giorgino   +4 more
doaj   +1 more source

A new general glucose homeostatic model using a proportional-integral-derivative controller [PDF]

, 2011
The glucose-insulin system is a challenging process to model due to the feedback mechanisms present, hence the implementation of a model-based approach to the system is an on-going and challenging research area.
S.M. Poucher, E.M. Watson, Chappell, M. J. (Michael J.), Yates, J. W. T., Ducrozet, F., M.J. Chappell, Poucher, S. M., J.W.T. Yates, Watson, E. M., F. Ducrozet   +9 more
core   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status

Frontiers in Physiology, 2018
Circadian rhythms can be perturbed by shift work, travel across time zones, many occupational tasks, or genetic mutations. Perturbed circadian rhythms are associated with the increasing problem of obesity, metabolic dysfunction, and insulin resistance ...
Astrid L. Basse, Emilie Dalbram, Louise Larsson, Zach Gerhart-Hines, Zach Gerhart-Hines, Juleen R. Zierath, Juleen R. Zierath, Jonas T. Treebak   +7 more
doaj   +1 more source

Influence of apolipoproteins on the association between lipids and insulin sensitivity: a cross-sectional analysis of the RISC study

, 2013
International audienceOBJECTIVE: We evaluated whether the association of insulin sensitivity with HDL cholesterol (HDL) and triglycerides is influenced by major plasma apolipoproteins, as suggested by recent experimental evidence.
Laville, Martine, Hojlund, Kurt, Monti, Lucilla, Natali, Andrea, Morgantini, Cecilia, Risc, Relationship Between Insulin Sensitivity And Cardiovascular Disease, ., Ferrannini, Ele, Bonnet, Fabrice, Baldi, Simona   +8 more
core   +1 more source

Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High‐Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non‐Invasive Diabetes Monitoring

Advanced Healthcare Materials, EarlyView.
An AuNPs/fMWCNT nanocomposite‐modified screen‐printed carbon electrode was engineered via sequential electrodeposition and integrated into a 3D‐printed microfluidic platform for ultrasensitive methylglyoxal detection. The non‐invasive sensing platform enables rapid analysis in saliva and sweat, highlighting strong potential for wearable point‐of‐care ...
Ahadul Amin Soshi, Md Younus Ali, Dadbeh Pazuki, Matiar M.R. Howlader   +3 more
wiley   +1 more source