Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease [PDF]
Frontiers in Aging NeuroscienceAlthough impaired insulin signaling in the brain has been recognized as a key factor in the development and progression of Alzheimer’s disease (AD), the underlying mechanisms remain incompletely understood.
Faruk Hossen +4 more
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Mechanisms and therapeutics of insulin signaling transduction genes in diabetic cardiomyopathy: a comprehensive updated review [PDF]
Frontiers in EndocrinologyDiabetic cardiomyopathy (DCM), a complication of type 2 diabetes mellitus (T2DM), is closely associated with key genes in the insulin signaling pathway.
Yufeng He +6 more
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Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men [PDF]
Diabetes & Metabolism Journal, 2020 BackgroundSouth Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance.
Laura G.M. Janssen +10 more
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E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling. [PDF]
PLoS ONE, 2016 Impaired proximal insulin signaling is often present in diabetes. Hence, approaches to enhance glucose disposal independent of proximal insulin signaling are desirable. Evidence indicates that Adenovirus-derived E4orf1 protein may offer such an approach.
Ha-Na Na +3 more
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Molecular Metabolism, 2023 Objectives: Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain.
Matthäus Metz +5 more
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Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. [PDF]
PLoS Genetics, 2013 Reduced insulin/IGF signaling increases lifespan in many animals. To understand how insulin/IGF mediates lifespan in Drosophila, we performed chromatin immunoprecipitation-sequencing analysis with the insulin/IGF regulated transcription factor dFOXO in ...
Hua Bai +3 more
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A genetic strategy to measure insulin signaling regulation and physiology in Drosophila.
PLoS Genetics, 2023 Insulin regulation is a hallmark of health, and impaired insulin signaling promotes metabolic diseases like diabetes mellitus. However, current assays for measuring insulin signaling in all animals remain semi-quantitative and lack the sensitivity ...
Deborah D Tsao +4 more
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Mekanisme Molekuler Dari Resistensi Insulin Pada Diabetes Melitus Tipe Dua
Majalah Kedokteran Andalas, 2022 Diabetes melitus merupakan kelainan endokrin yang paling sering ditemukan. Salah satu patofisiologi utamanya adalah resistensi jaringan target terhadap insulin.
Eva Decroli
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Insulin action at a molecular level – 100 years of progress
Molecular Metabolism, 2021 The discovery of insulin 100 years ago and its application to the treatment of human disease in the years since have marked a major turning point in the history of medicine.
Morris F. White, C. Ronald Kahn
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Organ Crosstalk and the Modulation of Insulin Signaling
Cells, 2021 A highly complex network of organ communication plays a key role in regulating metabolic homeostasis, specifically due to the modulation of the insulin signaling machinery. As a paradigm, the role of adipose tissue in organ crosstalk has been extensively
Alejandra Romero, Juergen Eckel
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