Results 11 to 20 of about 381,053 (217)
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes. [PDF]
PLoS ONE, 2012 REDD1 (Regulated in development and DNA damage response 1) is a hypoxia and stress response gene and is a negative regulator of mTORC1. Since mTORC1 is involved in the negative feedback loop of insulin signaling, we have studied the role of REDD1 on ...
Claire Regazzetti +5 more
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The brain as an insulin-sensitive metabolic organ
Molecular Metabolism, 2021 Background: The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function.
Joshua L. Milstein, Heather A. Ferris
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The role of C-peptide in regulation of the insulin signaling system (systematic review)
Сибирский научный медицинский журнал, 2021 The C-peptide is a fragment of proinsulin, the cleavage of which forms active insulin. In recent years, new evidence has emerged indicating that C-peptide is involved not only in the processing of insulin in the secretory granules of pancreatic β-cells ...
O. N. Poteryaeva, I. F. Usynin
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Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
Molecular Brain, 2018 Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus.
Hanwoong Woo +4 more
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E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling.
PLoS ONE, 2018 BackgroundType 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control.
Anuradha A Shastri +4 more
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Insulin controls food intake and energy balance via NPY neurons
Molecular Metabolism, 2017 Objectives: Insulin signaling in the brain has been implicated in the control of satiety, glucose homeostasis and energy balance. However, insulin signaling is dispensable in energy homeostasis controlling AgRP or POMC neurons and it is unclear which ...
Kim Loh +13 more
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eLife, 2020 In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates ...
Bryan A Martinez +9 more
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Insulin Signaling in Arthritis
Frontiers in Immunology, 2021 Inflammatory arthritis is burdened by an increased risk of metabolic disorders. Cytokines and other mediators in inflammatory diseases lead to insulin resistance, diabetes and hyperlipidemia.
Cesare Tripolino +10 more
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Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines
Mediators of Inflammation, 2018 We have previously reported that Epac1 reduced inflammatory cytokines, which is protective to the diabetic retina. We have also published that impaired insulin signaling occurs in the diabetic retina.
Elizabeth Curtiss +5 more
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Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling. [PDF]
PLoS ONE, 2010 The aim of the present study was to investigate whether the survival-improving effect of atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory pathways and, in parallel, an improvement in tissue insulin signaling in ...
Kelly Lima Calisto +7 more
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