Results 31 to 40 of about 19,209 (213)
Animal Models and Experimental Medicine, EarlyView.Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica +4 more
wiley +1 more source
Orvosi Hetilap, 2011 Authors present the history of a 56-year-old man who was evaluated for recurrent epigastrial pain. Clinical investigation revealed a 4-cm tumor in the head of the pancreas and a solitary liver metastasis. Pathological examination of the surgically excised pancreatic tumor indicated a moderately differentiated neuroendocrine carcinoma and Ki-67 ...
Miklós, Tóth +5 more
openaire +2 more sources
NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES
ChemMedChem, Accepted Article.Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti +4 more
wiley +1 more source
Endocrinology, Diabetes & Metabolism Case Reports, 2022 Acanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma,
Jenny S W Yun +3 more
doaj +1 more source
Insulinoma with focal hepatic lesions: malignant insulinoma? [PDF]
BMJ Case Reports, 2015 Insulinoma is a rare tumour that is malignant in only 10% of cases. We report a case of insulinoma in a 59-year-old woman, associated with focal liver lesions, which raised the suspicion of malignancy of a pancreatic tumour. Enucleation of the insulinoma was performed with wedge resection of one hepatic nodule.
Yossra Zidi-Mouaffek +3 more
openaire +3 more sources
Translational Oncology, 2022 Insulinomas are considered rare indolent neuroendocrine neoplasms in human medicine, however when metastases occur no curative treatment is available thus, novel therapies are needed.
Ylenia Capodanno +5 more
doaj
Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis. [PDF]
PLoS ONE, 2016 The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin.
Courtney Nosak +7 more
doaj +1 more source
Hyams Grade and Ki‐67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma
The Laryngoscope, EarlyView.The aim of the present study was to investigate the influence of various prognostic parameters on the occurrence of primary tumor progression and/or tumor recurrence (TPR) in esthesioneuroblastoma after primary curative therapy in a single center. Time to first TPR in esthesioneuroblastoma was significantly shorter in cases with a younger age and ...
Michael Koch +5 more
wiley +1 more source
Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis.
PLoS ONE, 2019 BACKGROUND:Previous studies on the diagnostic value of arterial calcium stimulation with hepatic venous sampling (ASVS) for the localization of insulinoma have reported inconsistent results.
Hao Wang, Ying Ba, Qian Xing, Run-Ce Cai
doaj +1 more source
Molecular Ecology Resources, EarlyView.ABSTRACT The percomorph fish clade Gobioidei is a suborder that comprises over 2200 species distributed in nearly all aquatic habitats. To understand the genetics underlying their species diversification, we sequenced and annotated the genome of the loach goby, Rhyacichthys aspro, an early‐diverging group, and compared it with nine additional Gobioidei
Tzi‐Yuan Wang +10 more
wiley +1 more source