Results 31 to 40 of about 20,757 (169)

A Case Report of Insulinoma Located with Calcium Stimulation Test

, 2014
Although rarely seen, insulinomas are the most common neuroendocrine tumors of the pancreas. It can be life threatening due to hypoglisemia. Diagnosis is base on clinical and laboratory findings. Radiological findings are helpful to confirm the diagnosis
Gülhan Akbaba, İlkay Akmangit, Mazhar Müslüm Tuna, Ayşe Arduç, Berçem Ayçiçek Doğan, Yasemin Tütüncü, Kerim Küçükler, Serdar Güler, Dilek Berker, Mazhar Müslüm Tuna, İlkay Akmangit   +10 more
core   +1 more source

Insulinoma

The article presents a description of a clinical case of insulinoma in a 69-year-old female patient. Insulinoma is a rare neuroendocrine tumor originating from the β-cells of the pancreas, the clinical manifestations of which are associated with ...
Renata I. Karimova, Tatyana V. Nikiforova, Olga V. Malyshkina, Elsa S. Gaisina   +3 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Incidence and risk factors for insulinoma diagnosed in dogs under primary veterinary care in the UK

Scientific Reports
Insulinoma is the most common pancreatic tumor diagnosed in dogs. This study aimed to report incidence risk, breed predispositions and other demographic risk factors for insulinoma diagnosed in dogs under primary veterinary care in the UK. The VetCompass
Kasper Kraai, Dan G. O’Neill, Lucy J. Davison, Dave C. Brodbelt, Sara Galac, Floryne O. Buishand   +5 more
doaj   +1 more source

Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma

Frontiers in Endocrinology
Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the
Run Ting Chin, Jolene Jiayu Kiew, Khek Yu Ho, Doddabele S. Deepak   +3 more
doaj   +1 more source

Accidental exposure to glimepiride from adulterated medication resulting in severe hypoglycaemia

Endocrinology, Diabetes & Metabolism Case Reports, 2022
Sulphonylureas are insulinotropic and are not only useful in patients with diabetes but also act in non-diabetic individuals where hypoglycaemia and hyperinsulinism mimic insulinoma.
Annabelle G Hayes, Mahesh M Umapathysivam, David J Torpy   +2 more
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Clinicopathological and immunohistochemical features of insulinoma in an adult mixed breed dog

Brazilian Journal of Veterinary Pathology, 2023
Canine insulinoma is a common non-specific neoplasm with high metastasizing ability. Its epidemiology, diagnosis, and treatment are well described. However, its long-term prognosis is considered poor.
Isabeli Joaquim Contel, Pedro Pol Ximenes, Fernando Carmona Dinau, Fernanda Barthelson Carvalho de Moura, Giovanna Gati de Souza, Iolanda Simões Braga, Isadora Fernanda Pelaquim, Rafael Torres Neto, Noeme Sousa Rocha   +8 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source