Results 51 to 60 of about 30,427 (262)

Malignant insulinoma [PDF]

Orvosi Hetilap, 2011
Authors present the history of a 56-year-old man who was evaluated for recurrent epigastrial pain. Clinical investigation revealed a 4-cm tumor in the head of the pancreas and a solitary liver metastasis. Pathological examination of the surgically excised pancreatic tumor indicated a moderately differentiated neuroendocrine carcinoma and Ki-67 ...
Miklós, Tóth, Nikolette, Szücs, Zsuzsa, Jakab, Attila, Doros, Zoltán, Nemes, Károly, Rácz   +5 more
openaire   +2 more sources

Surgical management, pre-operative tumor localization and histopathology of 80 patients operated for insulinoma.

Journal of Clinical Endocrinology and Metabolism, 2019
INTRODUCTION Diagnosis and pathological classifications is challenging in insulinomas. AIM To characterize insulinoma patients with regard to localization of tumors, surgery outcomes and histopathology.
Mikkel Andreassen, E. Ilett, D. Wiese, E. Slater, M. Klose, C. Hansen, Norman Gercke, S. Langer, A. Kjaer, E. Maurer, B. Federspiel, P. Kann, D. Bartsch, U. Knigge   +13 more
semanticscholar   +1 more source

Strategies for optimization of hypoglycemia rat models

Animal Models and Experimental Medicine, EarlyView.
This review focuses on rat models for studying the short‐term and long‐term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study sheds light on uncovering the therapeutic potential for hypoglycemic patients and its efficacy in mitigating ...
Lee Yeong Zher, Eason Kong Qi Zheng, Rayneshia Elaura Raymond, Ye Zhen Jie, Christina Gertrude Yap   +4 more
wiley   +1 more source

Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

Animal Models and Experimental Medicine, EarlyView.
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica, Suzana Stanisavljević, Dragica Mićanović, Ivana Stojanović, Đorđe Miljković   +4 more
wiley   +1 more source

Pancreatic insulinoma causing hypoglycemic episodes

Journal of Pediatric Surgery Case Reports, 2020
Background: Insulinoma typically has non-specific neuroglycopenic symptoms. It is a neuroendocrine tumor of the pancreas, and leads to recurring hypoglycemic attacks stemming from insulin hypersecretion.
Moaffaq Mahdi, Bassel Almehman, Safi Nassan, Soliman Binyahib   +3 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, EarlyView.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Light‐Mediated Insulin and Amylin Secretion: Influence of Irradiation Parameters in Optogenetically Modified Mouse‐Pancreatic β Cells

Journal of Biophotonics, EarlyView.
This study demonstrates variation in photo‐induced secretion of insulin and amylin from Channelrhodopsin‐2 expressing MIN6 cells under different irradiation conditions. For the first time, an alteration in the relative ratio of amylin: insulin is observed with varying irradiation conditions.
Nidhi Maharwal, Rashmi Shrivastava, Khageswar Sahu, Shovan Kumar Majumder   +3 more
wiley   +1 more source

Hyams Grade and Ki‐67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma

The Laryngoscope, EarlyView.
The aim of the present study was to investigate the influence of various prognostic parameters on the occurrence of primary tumor progression and/or tumor recurrence (TPR) in esthesioneuroblastoma after primary curative therapy in a single center. Time to first TPR in esthesioneuroblastoma was significantly shorter in cases with a younger age and ...
Michael Koch, Mathias Balk, Sven Schlaffer, Abbas Agaimy, Heinrich Iro, Sarina Müller   +5 more
wiley   +1 more source

INSULINOMA MALIGNO

Revista de la Facultad de Medicina Humana, 2017
El insulinoma es el tumor neuroendocrino del páncreas más frecuente. Se presenta el caso de un paciente de 54 años de edad. La sintomatología conocida por la disminución severa de la glicemia en el sistema nervioso central, el diagnostico se basó en la evidencia de hipoglicemia, asociado a niveles elevados de insulina.
Herrera-Favian, Pedro Roberto, Flores-Delgado, César Alejandro, Hererra-Fernandez, Roy   +2 more
openaire   +4 more sources

Effects of Genistein on Inflammasome Induced Pancreatic β‐Cell Apoptosis by Dexamethasone

Molecular Nutrition &Food Research, EarlyView.
The possible mechanism of genistein‐mediated protection against dexamethasone‐induced pancreatic β‐cell apoptosis. Genistein decreases the activation of IRE‐1α, resulting in the reduction of sXBP1, JNK, TXNIP, NLRP3, and IL‐1β expression. Genistein inhibits dexamethasone‐induced pancreatic β‐cell apoptosis.
Nattinee Jitprawet, Jatuporn Sujjitjoon, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source