Results 101 to 110 of about 75,567 (173)

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

The FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.
Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun   +3 more
wiley   +1 more source

Characterization of the Functional Domains of Human Foamy Virus Integrase Using Chimeric Integrases

Molecules and Cells, 2005
Retroviral integrases insert viral DNA into target DNA. In this process they recognize their own DNA specifically via functional domains. In order to analyze these functional domains, we constructed six chimeric integrases by swapping domains between HIV-1 and HFV integrases, and two point mutants of HFV integrase.
Hak Sung, Lee, Seung Yi, Kang, Cha-Gyun, Shin   +2 more
openaire   +2 more sources

Efficacy and safety of bictegravir/emtricitabine/tenofovir alafenamide in Black and Hispanic/Latine adults with HIV‐1 initiating first‐line therapy: 5‐year follow‐up from two phase III studies

HIV Medicine, Volume 26, Issue 6, Page 858-869, June 2025.
Abstract Introduction Black and Hispanic/Latine people are disproportionately affected by HIV‐1 and may have a greater risk of comorbidities than non‐Black and non‐Hispanic/Latine people with HIV. However, they have historically been underrepresented in HIV clinical studies.
C. Martorell, M. Ramgopal, D. Hagins, O. Osiyemi, J. R. Arribas, M. Berhe, Y. Yazdanpanah, C. Orkin, L. Santiago, C. Rosero, N. Unger, H. Liu, R. Rogers, J. T. Hindman, A. Wurapa   +14 more
wiley   +1 more source

Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health

HIV Medicine, Volume 26, Issue 6, Page 879-887, June 2025.
Abstract Purpose HIV outcome changed drastically with antiretroviral (ARV) therapy, especially after the introduction of second‐generation integrase strand transfer inhibitors (INSTIs). Despite these advances, however, chronic immune activation and exhaustion, marked by programmed cell death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) upregulation ...
Bogusz Aksak‐Wąs, Karolina Skonieczna‐Żydecka, Miłosz Parczewski, Rafał Hrynkiewicz, Filip Lewandowski, Karol Serwin, Kaja Mielczak, Franciszek Lenkiewicz, Paulina Niedźwiedzka‐Rystwej   +8 more
wiley   +1 more source

SITE-SPECIFIC RECOMBINATION OF THE MYCOBACTERIUM TUBERCULOSISPROPHAGE-LIKE ELEMENT PHIRV1 [PDF]

, 2004
The site-specific recombination systems of bacteriophages and other mobile elements fall into two categories that are named for the integrase protein that catalyzes integration and excision of the phage genome.
Bibb, Lori Ann
core  

Late diagnosis of HIV among Ukrainian refugees in the Czech Republic: A retrospective, observational study

HIV Medicine, Volume 26, Issue 6, Page 888-898, June 2025.
Abstract Objectives This retrospective, observational, non‐interventional study describes the demographics, characteristics, immunological and virological status, coinfections, healthcare unit of HIV diagnosis and follow‐up status of Ukrainian refugees with newly diagnosed HIV in the Czech Republic, with a special focus on those with a late HIV ...
Zofia Bartovská, Ricardo Massmann, David Jilich, Tomáš Groh, Lukáš Fleischhans, Milan Zlámal, Radek Svačinka, David Vydrář, Dalibor Sedláček, Miroslav Kubiska, Jaroslav Kapla, Lucie Nepovímová, Daniela Bartková, Lenka Olbrechtová, Zdeňka Jerhotová, Eva Novotná, Jakub Wnuk, Vratislav Němeček, Pavel Dlouhý, Štěpán Cimrman, Marek Malý   +20 more
wiley   +1 more source

Effect of Pyrolysis on the Removal of Antibiotic Resistance Genes and Class I Integrons from Municipal Wastewater Biosolids [PDF]

, 2018
Wastewater biosolids represent a significant reservoir of antibiotic resistance genes (ARGs). While current biosolids treatment technologies can reduce ARG levels in residual wastewater biosolids, observed removal rates vary substantially.
Kappell, Anthony D., Kimbell, Lee, McNamara, Patrick J.   +2 more
core   +1 more source

Safety and effectiveness of switch to bictegravir/emtricitabine/tenofovir alafenamide following dual regimen therapy in people with HIV: Insights from the Icona cohort

HIV Medicine, Volume 26, Issue 6, Page 970-977, June 2025.
Abstract Objectives Most treatment switches are for simplification from three‐drug (3DR) to dual regimens (2DR). However, a proportion of people with HIV may switch back to 3DR, like bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) after 2DR.
Andrea De Vito, Alessandro Tavelli, Alessandro Cozzi‐Lepri, Andrea Giacomelli, Roberto Rossotti, Giacomo Ponta, Nicoletta Bobbio, Alice Ianniello, Antonella Cingolani, Giordano Madeddu, Andrea Antinori, Antonella d'Arminio Monforte, on behalf of ICONA Foundation Study Group, A. d'Arminio Monforte, A. Antinori, S. Antinori, A. Castagna, R. Cauda, G. Di Perri, E. Girardi, R. Iardino, A. Lazzarin, G. C. Marchetti, C. Mussini, E. Quiros‐Roldan, L. Sarmati, B. Suligoi, F. Von Schloesser, P. Viale, A. d'Arminio Monforte, A. Antinori, A. Castagna, F. Ceccherini‐Silberstein, A. Cingolani, A. Cozzi‐Lepri, A. Di Biagio, E. Girardi, A. Gori, S. Lo Caputo, G. Marchetti, F. Maggiolo, C. Mussini, M. Puoti, C. F. Perno, C. Torti, A. Antinori, A. Bandera, S. Bonora, A. Calcagno, D. Canetti, A. Castagna, F. Ceccherini‐Silberstein, A. Cervo, A. Cingolani, P. Cinque, A. Cozzi‐Lepri, A. d'Arminio Monforte, A. Di Biagio, R. Gagliardini, A. Giacomelli, E. Girardi, N. Gianotti, A. Gori, G. Guaraldi, S. Lanini, G. Lapadula, M. Lichtner, A. Lai, S. Lo Caputo, G. Madeddu, F. Maggiolo, V. Malagnino, G. Marchetti, A. Mondi, V. Mazzotta, C. Mussini, S. Nozza, C. F. Perno, S. Piconi, C. Pinnetti, M. Puoti, E. Quiros Roldan, R. Rossotti, S. Rusconi, M. M. Santoro, A. Saracino, L. Sarmati, V. Spagnuolo, N. Squillace, V. Svicher, L. Taramasso, C. Torti, A. Vergori, A. Cozzi‐Lepri, S. De Benedittis, I. Fanti, M. Giotta, C. Marelli, A. Rodano, A. Tavelli, M. Cernuschi, L. Cosmaro, A. Perziano, V. Calvino, D. Russo, M. Farinella, N. Policek, V. L. Del Negro, M. Augello, S. Carrara, S. Graziano, G. Prota, S. Truffa, D. Vincenti, R. Rovito, M. Sgarlata, I. A Giacometti, A. Costantini, V. Barocci, A. Saracino, C. Santoro, E. Milano, L. Comi, C. Suardi, P. Viale, L. Badia, S. Cretella, E. M. Erne, A. Pieri, E. Quiros Roldan, E. Focà, B. Menzaghi, C. Abeli, L. Chessa, F. Pes, P. Maggi, L. Alessio, G. Nunnari, B. M. Celesia, J. Vecchiet, K. Falasca, A. Pan, S. Dal Zoppo, D. Segala, F. Bartalesi, C. Costa, S. Lo Caputo, S. Ferrara, M. Bassetti, E. Pontali, S. Blanchi, N. Bobbio, C. Del Borgo, R. Marocco, G. Mancarella, S. Piconi, C. Molteni, S. Rusconi, G. Canavesi, G. Pellicanò, G. Marchetti, S. Antinori, G. Rizzardini, M. Puoti, A. Castagna, A. Bandera, V. Bono, M. V. Cossu, A. Giacomelli, R. Lolatto, M. C. Moioli, L. Pezzati, S. Diotallevi, C. Tincati, C. Mussini, M. Menozzi, P. Bonfanti, G. Lapadula, V. Sangiovanni, I. Gentile, V. Esposito, N. Coppola, F. M. Fusco, G. Di Filippo, V. Rizzo, N. Sangiovanni, S. Martini, A. M. Cattelan, D. Leoni, A. Cascio, M. Trizzino, D. Francisci, E. Schiaroli, G. Parruti, F. Sozio, D. Messeri, S. I. Bonelli, C. Lazzaretti, R. Corsini, A. Antinori, R. Cauda, C. Mastroianni, L. Sarmati, A. Latini, A. Cingolani, I. Mastrorosa, S. Lamonica, M. Capozzi, M. Camici, I. Mezzaroma, M. Rivano Capparuccia, G. Iaiani, C. Stingone, L. Gianserra, J. Paulicelli, M. M. Plazzi, G. d'Ettore, M. Fusto, M. Lichtner, I. Coledan, G. Madeddu, A. De Vito, M. Fabbiani, F. Montagnani, A. Franco, R. Fontana Del Vecchio, D. Francisci, C. Di Giuli, G. C. Orofino, G. Calleri, G. Di Perri, S. Bonora, G. Accardo, C. Tascini, A. Londero, G. Battagin, S. Nicolè, G. Starnini, S. Dell'Isola   +238 more
wiley   +1 more source

CARE1, a TY3-gypsy long terminal repeat retrotransposon in the food legume chickpea (Cicer arietinum L) [PDF]

, 2007
We report a novel Ty3-gypsy long terminal repeat retrotransposon CARE1 (_Cicer arietinum_ retro-element 1) in chickpea. This 5920-bp AT-rich (63%) element carries 723-bp 5' and 897-bp 3' LTRs respectively flanking an internal region of 4300-bp.
Kailash C. Upadhyaya, Manoj D. R. Rajput
core   +1 more source

Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK [PDF]

, 2013
Alderton, W K, Anderson, Rosaleen, Collingwood, S P, Pryde, D C   +3 more
core   +1 more source