Results 101 to 110 of about 54,271 (286)

Control of serine integrase recombination directionality by fusion with the directionality factor

Nucleic Acids Research, 2017
Bacteriophage serine integrases are extensively used in biotechnology and synthetic biology for assembly and rearrangement of DNA sequences. Serine integrases promote recombination between two different DNA sites, attP and attB, to form recombinant attL ...
F. J. Olorunniji, Arlene L Mcpherson, S. Rosser, Margaret C. M. Smith, S. Colloms, W. Stark   +5 more
semanticscholar   +1 more source

Efficacy and safety of bictegravir/emtricitabine/tenofovir alafenamide in Black and Hispanic/Latine adults with HIV‐1 initiating first‐line therapy: 5‐year follow‐up from two phase III studies

HIV Medicine, EarlyView.
Abstract Introduction Black and Hispanic/Latine people are disproportionately affected by HIV‐1 and may have a greater risk of comorbidities than non‐Black and non‐Hispanic/Latine people with HIV. However, they have historically been underrepresented in HIV clinical studies.
C. Martorell, M. Ramgopal, D. Hagins, O. Osiyemi, J. R. Arribas, M. Berhe, Y. Yazdanpanah, C. Orkin, L. Santiago, C. Rosero, N. Unger, H. Liu, R. Rogers, J. T. Hindman, A. Wurapa   +14 more
wiley   +1 more source

GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

Scientific Reports, 2017
GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection.
A. Jaspart, C. Calmels, O. Cosnefroy, P. Bellecave, P. Pinson, S. Claverol, V. Guyonnet-Duperat, B. Dartigues, M. S. Benleulmi, E. Mauro, P. Gretteau, V. Parissi, M. Métifiot, M. Andreola   +13 more
semanticscholar   +1 more source

Assessing weight change in adolescents and young adults with perinatally acquired HIV and integrase inhibitor use

HIV Medicine, EarlyView.
Abstract Introduction Integrase strand transfer inhibitors (INSTIs) are the mainstay of treatment in adults and children living with HIV. Weight gain has been associated with INSTI use in adults; however, less data exist on its effects on younger patients.
Kathleen J. Pincus, Nabila Faridi, Patrick Amadeus Ryscavage, Hyunuk Seung, Kristine A. Parbuoni, Matthew Grant, Neha Sheth Pandit   +6 more
wiley   +1 more source

Combining Alchemical Transformation with Physical Pathway to Accurately Compute Absolute Binding Free Energy [PDF]

arXiv, 2018
We present a new method that combines alchemical transformation with physical pathway to accurately and efficiently compute the absolute binding free energy of receptor-ligand complex. Currently, the double decoupling method (DDM) and the potential of mean force approach (PMF) methods are widely used to compute the absolute binding free energy of ...
arxiv  

Bxb1 integrase serves as a highly efficient DNA recombinase in rapid metabolite pathway assembly

Acta Biochimica et Biophysica Sinica, 2017
Phage-encoded serine integrases are widely used in genetic engineering. They also have the potential to serve as efficient DNA assemblers, demonstrated by the method of site-specific recombination-based tandem assembly (SSRTA) that can combine biological
Xianwei Wang, Biao Tang, Yu Ye, Y. Mao, X. Lei, Guoping Zhao, Xiaoming Ding   +6 more
semanticscholar   +1 more source

Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health

HIV Medicine, EarlyView.
Abstract Purpose HIV outcome changed drastically with antiretroviral (ARV) therapy, especially after the introduction of second‐generation integrase strand transfer inhibitors (INSTIs). Despite these advances, however, chronic immune activation and exhaustion, marked by programmed cell death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) upregulation ...
Bogusz Aksak‐Wąs, Karolina Skonieczna‐Żydecka, Miłosz Parczewski, Rafał Hrynkiewicz, Filip Lewandowski, Karol Serwin, Kaja Mielczak, Franciszek Lenkiewicz, Paulina Niedźwiedzka‐Rystwej   +8 more
wiley   +1 more source

The Molecular Biology of HIV Integrase [PDF]

Future Virology, 2012
Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that catalyzes DNA integration, have recently been approved and more are in the pipeline. These drugs bind to an intermediate in DNA integration called the intasome, in
openaire   +3 more sources

Late diagnosis of HIV among Ukrainian refugees in the Czech Republic: A retrospective, observational study

HIV Medicine, EarlyView.
Abstract Objectives This retrospective, observational, non‐interventional study describes the demographics, characteristics, immunological and virological status, coinfections, healthcare unit of HIV diagnosis and follow‐up status of Ukrainian refugees with newly diagnosed HIV in the Czech Republic, with a special focus on those with a late HIV ...
Zofia Bartovská, Ricardo Massmann, David Jilich, Tomáš Groh, Lukáš Fleischhans, Milan Zlámal, Radek Svačinka, David Vydrář, Dalibor Sedláček, Miroslav Kubiska, Jaroslav Kapla, Lucie Nepovímová, Daniela Bartková, Lenka Olbrechtová, Zdeňka Jerhotová, Eva Novotná, Jakub Wnuk, Vratislav Němeček, Pavel Dlouhý, Štěpán Cimrman, Marek Malý   +20 more
wiley   +1 more source

HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination

Cell Death and Disease, 2017
Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome.
Mayilaadumveettil Nishana, N. Nilavar, Rupa Kumari, Monica Pandey, S. Raghavan   +4 more
semanticscholar   +1 more source