Results 111 to 120 of about 84,131 (280)

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

Molecular Therapy: Nucleic Acids, 2014
HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin.
Muhammad Qamar Saeed, Noelle Dufour, Cynthia Bartholmae, Urzula Sieranska, Malaika Knopf, Eloïse Thierry, Sylvain Thierry, Olivier Delelis, Nicolas Grandchamp, Héloïse Pilet, Philippe Ravassard, Julie Massonneau, Françoise Pflumio, Christof von Kalle, François Lachapelle, Alexis-Pierre Bemelmans, Manfred Schmidt, Ché Serguera   +17 more
doaj   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Insights into the Functions of a Prophage Recombination Directionality Factor

Viruses, 2012
Recombination directionality factors (RDFs), or excisionases, are essential players of prophage excisive recombination. Despite the essentially catalytic role of the integrase in both integrative and excisive recombination, RDFs are required to direct ...
Mireille Ansaldi, Vincent Méjean, Gaël Panis, Nathalie Franche   +3 more
doaj   +1 more source

Patient‐reported outcomes in clinical trials assessing the effectiveness of cabotegravir + rilpivirine long‐acting injections as antiretroviral therapy: A systematic review

HIV Medicine, EarlyView.
Abstract Introduction: Human immunodeficiency virus‐1 (HIV‐1) continues to have a high global burden, with approximately 39.9 million people currently living with the virus. Despite the clinical success of antiretroviral therapy (ART), adherence remains a significant challenge, often due to emotional distress and HIV‐related stigma.
Dhruv Vinay, Iresh Jayaweera, Meghan Bowman, Don Thiwanka D Wijeratne   +3 more
wiley   +1 more source

Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Nature Communications, 2019
Long-acting formulation of the integrase inhibitor cabotegravir (CAB LA) is in clinical development for HIV pre-exposure prophylaxis (PrEP). Here, using a SHIV macaque model, the authors show emergence of integrase mutations associated to CAB LA PrEP ...
Jessica Radzio-Basu, Olivia Council, Mian-er Cong, Susan Ruone, Alicia Newton, Xierong Wei, James Mitchell, Shanon Ellis, Christos J. Petropoulos, Wei Huang, William Spreen, Walid Heneine, J. Gerardo García-Lerma   +12 more
doaj   +1 more source

From ligand to complexes: inhibition of HIV-1 Integrase by beta-diketo acid metal complexes [PDF]

, 2006
Recently, a class of compounds bearing a β-diketo acid moiety have emerged as the most promising lead in anti-HIV-1 IN drug discovery. It is believed that the β-diketo acid pharmacophoric motif could be involved in a functional sequestration of one or ...
Al-Mawsawi, Laith Q., Bacchi, Alessia, Carcelli, Mauro, Derudas, Marco, Fisicaro, Emilia, Gates, Paul, Neamati, Nouri, Rogolino, Dominga, Sechi, Mario   +8 more
core  

HIV Dynamics and Integrase Inhibitors

Antiviral Chemistry and Chemotherapy, 2009
The integrase inhibitor (INI) raltegravir has shown promising results in clinical trials to date, reducing second phase HIV RNA levels by 70% in comparison with standard regimens. These trial results have been limited by the 50 copies/ml detection limit of the HIV RNA assay and have not investigated the effect of an INI regimen on levels of latently ...
openaire   +3 more sources

Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus‐1 (HIV‐1): A systematic literature review of clinical and patient‐reported outcomes

HIV Medicine, EarlyView.
Abstract Background Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor‐based single‐tablet regimen, is recommended for rapid start in US and
Jade Ghosn, Jeremy Chow, Monica Gandhi, Miguel Górgolas, Aws Al‐Hayani, Hansel Tookes, Max Lee, Emily F. Kaiser, David Malebranche, Fernando Alvarez Bognar, Bhumi Gandhi‐Patel, Lili Dai   +11 more
wiley   +1 more source

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands [PDF]

, 2002
We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading
Kapur, Vivek, McCormick, John K., Orwin, Paul M., Paustian, Michael L., Schlievert, Patrick M., Yarwood, Jeremy M.   +5 more
core  

Tangle Solutions for a Family of DNA-Rearranging Proteins

, 2004
We study two systems of tangle equations that arise when modeling the action of the Integrase family of proteins on DNA. These two systems--direct and inverted repeats--correspond to two different possibilities for the initial DNA sequence.
Buck, Dorothy, Marcotte, Cynthia Verjovsky   +1 more
core   +1 more source