Results 121 to 130 of about 54,271 (286)

Weight gain, obesity, and the impact of lifestyle factors among people living with HIV: A systematic review

Obesity Reviews, EarlyView.
Summary HIV remains a significant health concern, but the advent of antiretroviral therapy (ART) has transformed it into a manageable chronic condition. However, weight gain and obesity pose a substantial challenge for people living with HIV (PLWH). Moreover, the role of lifestyle has not yet been comprehensively investigated.
Giulia Gilberti, Giorgio Tiecco, Silvia Marconi, Monica Marullo, Barbara Zanini, Eugenia Quiros‐Roldan   +5 more
wiley   +1 more source

Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors

Viruses, 2010
The HIV-1 integrase enzyme is essential for integrating the viral DNA into the host chromosome. Infection is aborted in the absence of integration, making integrase an attractive antiviral target. Recently approved inhibitors of integrase bind tightly to
Robert Craigie, Zhiqi Yin
doaj   +1 more source

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

Journal of Virology, 2015
During virion maturation, HIV-1 capsid protein assembles into a conical core containing the viral ribonucleoprotein (vRNP) complex, thought to be composed mainly of the viral RNA and nucleocapsid protein (NC).
J. Fontana, K. Jurado, N. Cheng, Ngoc L. Ly, J. Fuchs, R. Gorelick, A. Engelman, A. Steven   +7 more
semanticscholar   +1 more source

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

eLife, 2019
ABSTRACTA large number of HIV-1 integrase (IN) alterations, referred to as class II substitutions, exhibit pleotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of three distinct ...
Elliott, Jennifer, Eschbach, Jenna E., Koneru, Pratibha C., Li, Wen, Chavez, Maritza Puray, Townsend, Dana, Lawson, Dana, Engelman, Alan N., Kvaratskhelia, Mamuka, Kutluay, Sebla B.   +9 more
openaire   +6 more sources

Fitness Impaired Drug Resistant HIV-1 Is Not Compromised in Cell-to-Cell Transmission or Establishment of and Reactivation from Latency

Viruses, 2014
Both the presence of latently infected cells and cell-to-cell viral transmission are means whereby HIV can partially evade the inhibitory activities of antiretroviral drugs.
Sophie M. Bastarache, Thibault Mesplède, Daniel A. Donahue, Richard D. Sloan, Mark A. Wainberg   +4 more
doaj   +1 more source

Integrase inhibitor (INI) genotypic resistance in treatment-naive and raltegravir-experienced patients infected with diverse HIV-1 clades

Journal of Antimicrobial Chemotherapy, 2015
Objectives The aim of this study was to characterize the prevalence and patterns of genotypic integrase inhibitor (INI) resistance in relation to HIV-1 clade.
T. Doyle, D. Dunn, F. Ceccherini‐Silberstein, C. de Mendoza, Frederico Garcia, E. Smit, E. Fearnhill, A. Marcelin, J. Martinez-Picado, R. Kaiser, A. Geretti   +10 more
semanticscholar   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 ...
Daria J Hazuda
doaj   +1 more source

Primary resistance to integrase strand-transfer inhibitors in Europe.

Journal of Antimicrobial Chemotherapy, 2015
OBJECTIVES The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance.
M. Casadellà, P. M. V. Ham, M. Noguera-Julián, M. Noguera-Julián, A. V. Kessel, Christian Pou, L. Hofstra, José R. Santos, F. J. García, D. Struck, I. Alexiev, A. B. Kran, A. Hoepelman, L. Kostrikis, S. Somogyi, K. Liitsola, M. Linka, C. Nielsen, D. Oțelea, D. Paraskevis, Mario Poljak, E. Puchhammer-Stöckl, D. Staneková, Maja Stanojevic, K. V. Laethem, S. Z. Lepej, B. Clotet, B. Clotet, C. Boucher, R. Paredes, R. Paredes, A. Wensing   +31 more
semanticscholar   +1 more source

Characterization of the cryptic lambdoid prophage DLP12 of Escherichia coli and overlap of the DLP12 integrase gene with the tRNA gene argU [PDF]

, 1989
David F. Lindsey, D A Mullin, James R. Walker   +2 more
openalex   +1 more source