Results 121 to 130 of about 84,131 (280)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

eLife, 2019
ABSTRACTA large number of HIV-1 integrase (IN) alterations, referred to as class II substitutions, exhibit pleotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of three distinct ...
Elliott, Jennifer, Eschbach, Jenna E., Koneru, Pratibha C., Li, Wen, Chavez, Maritza Puray, Townsend, Dana, Lawson, Dana, Engelman, Alan N., Kvaratskhelia, Mamuka, Kutluay, Sebla B.   +9 more
openaire   +6 more sources

Weight gain on tenofovir alafenamide fumarate‐based therapy compared to tenofovir disoproxil fumarate‐ and abacavir‐based therapy in children and young people living with HIV in Europe

HIV Medicine, EarlyView.
Abstract Objective To compare BMI‐for‐age z‐score (zBMI) changes in treatment‐experienced children and young people living with HIV aged 6 to <25 years on tenofovir alafenamide fumarate (TAF) to those on tenofovir disoproxil fumarate (TDF) and abacavir (ABC).
The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) Study Group, Siobhan Crichton, Hannah Castro, Katja Doerholt, Luminita Ene, Luisa Galli, Tessa Goetghebuer, Sannie Brit Nordly, Christoph Königs, Magdalena Marczynska, Andrea Marongiu, Lars Navér, Marisa Navarro, Antoni Noguera‐Julian, Paolo Paioni, Vana Spoulou, Vinicius Vieira, Charlotte Jackson, Intira Jeannie Collins, Ali Judd, Elizabeth Chappell, Laura Calle Miguel, Borja Guarch‐Ibáñez, John O'Rourke, Katia Prime, Beatriz Ruiz‐Saez, Sandra Soeria‐Atmadja, Anna Turkova   +27 more
wiley   +1 more source

Metabolic dysfunction‐associated liver disease predicts incident liver fibrosis in people with HIV mono‐infection: A cohort study

HIV Medicine, EarlyView.
Abstract Introduction Metabolic dysfunction‐associated liver disease (MASLD) might progress to cirrhosis. We aimed to evaluate the association of MASLD with the risk of developing clinically significant fibrosis (CSF) in people living with HIV (PLWH).
Juliana Fittipaldi, Sandra W. Cardoso, Estevão Portela Nunes, Cristiane Fonseca De Almeida, Patricia Dias De Brito, Valdilea G. Veloso, Beatriz Grinsztejn, Hugo Perazzo   +7 more
wiley   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 ...
Daria J Hazuda
doaj   +1 more source

Characterization of the cryptic lambdoid prophage DLP12 of Escherichia coli and overlap of the DLP12 integrase gene with the tRNA gene argU [PDF]

, 1989
David F. Lindsey, D A Mullin, James R. Walker   +2 more
openalex   +1 more source

Retrotransposon Tto1: functional analysis and engineering for insertional mutagenesis [PDF]

, 2011
Retrotransposons are genomic parasites activated by stress conditions that can be seriously detrimental for their host. In this work I demonstrate that Tto1, a typical plant LTR retrotransposon with insertion preference into genes can be turned into a ...
Tramontano, Andrea, Tramontano, Andrea, Tramontano, Andrea   +2 more
core  

The association between HIV drug resistance testing, viral suppression and mortality in Ontario: a retrospective cohort study

HIV Medicine, EarlyView.
Abstract Background Drug resistance compromises the effectiveness of antiretroviral therapy (ART). Resistance testing prior to initiating therapy is recommended in guidelines in many high‐income countries, and it has been shown to improve outcomes after first‐line ART regimen failure. There is limited evidence on its role in treatment‐naïve individuals.
Lawrence Mbuagbaw, Carmen H. Logie, Lehana Thabane, Fiona Smaill, Marek Smieja, Ann N. Burchell, Beth Rachlis, Jean Eric Tarride, Abigail E. Kroch, Tony Mazzulli, Elizabeth Alvarez, Francis Nguyen, Richard Perez, Cristian Garcia, Jessyca Matos Silva, Hsien Seow   +15 more
wiley   +1 more source

Cloning, Expression, and In Vitro Functional Activity Assay of phiC31 Integrase cDNA in Escherichia coli [PDF]

Cell Journal, 2013
Objective: The aim of present study was cloning and expression of phiC31 integrase cDNA in a bacterial expression vector. Thus, an intra molecular assay vector was applied to show in vitro activity of recombinant protein.Materials and Methods: In this ...
Mohammad Hadi Sekhavati, Mojtaba Tahmoorespur, Kamran Ghaedi, Kianoush Dormiani, Pharm, Mohammad Reza Nassiri, Yahya Khazaie, Mahboubeh Foruzanfar, Morteza Hosseini, Mohammad Hossein Nasr Esfahani   +8 more
doaj  

A high-throughput, non-radioactive microtiter plate assay for activity of the human immunodeficiency virus integrase protein [PDF]

, 1994
Cornelis Vink, Martin S. Banks, Richard C. Bethell, Ronald H.A. PIasterk   +3 more
openalex   +1 more source

Cardiovascular risk knowledge stratified by predicted cardiovascular risk level among people living with HIV attending a tertiary HIV care centre in Gaborone, Botswana: A cross‐sectional study

HIV Medicine, EarlyView.
Abstract Objectives While people living with HIV are at an increased risk of cardiovascular disease (CVD), the level of awareness of CVD risk in this population is not well documented. This study aimed to assess the association between CVD risk factor knowledge and estimated CVD risk among people living with HIV.
Bernard Morapedi, Onkabetse Julia Molefe‐Baikai, Onkarabile Hiri, Kago Kebotsamang, Thato Moshomo, Mosepele Mosepele   +5 more
wiley   +1 more source