Results 91 to 100 of about 31,694 (314)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Control of serine integrase recombination directionality by fusion with the directionality factor [PDF]

, 2017
Bacteriophage serine integrases are extensively used in biotechnology and synthetic biology for assembly and rearrangement of DNA sequences. Serine integrases promote recombination between two different DNA sites, attP and attB, to form recombinant attL ...
Akopian, Arlene L. McPherson, Arnold, Bonnet, Bonnet, Brophy, Brown, Colloms, Fan, Farruggio, Femi J. Olorunniji, Fogg, Ghosh, Khaleel, Kilbride, Kuhstoss, Ladurner, Lewis, Mandali, Maranhao, Margaret C.M. Smith, Moore, Olorunniji, Olorunniji, Olorunniji, Olorunniji, Olorunniji, Pokhilko, Prorocic, Proudfoot, Roquet, Rowley, Rutherford, Rutherford, Sean D. Colloms, Smith, Susan J. Rosser, Van Duyne, W. Marshall Stark, Weinberg, Xu, Yang, Zhang, Zhang   +43 more
core   +3 more sources

HIV Integrase Inhibitors

, 2013
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Métifiot, Mathieu, Marchand, Christophe, Pommier, Yves   +2 more
openaire   +3 more sources

Factors Influencing the Binding of HIV‐1 Protease Inhibitors: Insights from Machine Learning Models

ChemMedChem, Accepted Article.
HIV‐1 protease inhibitors are crucial for antiviral therapies targeting acquired immunodeficiency syndrome (AIDS). Hundreds of HIV‐1 protease complexes with various ligands have been resolved and deposited in the Protein Data Bank. However, binding affinity measurements for these ligands are not always available.
Yaffa Shalit, Inbal Tuvi-Arad
wiley   +1 more source

Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2010
Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined.We identified 29 individuals who exhibited evidence of incomplete viral suppression on a regimen containing an integrase
Wei Huang, Christos J. Petropoulos, Hiroyu Hatano, Harry Lampiris, Harry Lampiris, Signe Fransen, David R. Bangsberg, Jeffrey N. Martin, Rebecca Hoh, Soumi Gupta, Jacob Lalezari, Steven G. Deeks   +11 more
openaire   +3 more sources

A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent dosing and self‐administration. This phase 1, double‐blind, randomized
Kelong Han, Paul Benn, Jörg Sievers, David Dorey, Michael Warwick‐Sanders, Randa Hareedy, Louise Harkness, Claudia Leemereise, Kjersten Offenbecker, Christina Donatti, Darin B. Brimhall, Christian Schwabe, Craig Boyle, Michael A. Hassman, Steve Knowles, Ronald D'Amico, William R. Spreen   +16 more
wiley   +1 more source

Attachment site recognition and regulation of directionality by the serine integrases

Nucleic Acids Research, 2013
Serine integrases catalyze the integration of bacteriophage DNA into a host genome by site-specific recombination between ‘attachment sites’ in the phage (attP) and the host (attB).
K. Rutherford, P. Yuan, K. Perry, R. Sharp, G. V. Van Duyne   +4 more
semanticscholar   +1 more source

Filamentous phages of Ralstonia solanacearum: Double-edged swords for pathogenic bacteria

Frontiers in Microbiology, 2013
Some phages from genus Inovirus use host or bacteriophage-encoded site-specific integrases or recimbinases establish a prophage state. During integration or excision, a superinfective form can be produced.
Takashi eYamada
doaj   +1 more source

Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors

Journal of Global Antimicrobial Resistance, 2020
This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this drug class.The emergence of INSTI-RMs and integrase evolution (estimated as genetic distance between integrase ...
Scutari, Rossana, Alteri, Claudia, Vicenti, Ilaria, Carlo, Domenico Di, Zuccaro, Valentina, Incardona, Francesca, Borghi, Vanni, Bezenchek, Antonia, Andreoni, Massimo, Antinori, Andrea, Perno, Carlo Federico, Cascio, Antonio, De Luca, Andrea, Zazzi, Maurizio, Santoro, Maria Mercedes   +14 more
openaire   +9 more sources

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source