Results 91 to 100 of about 18,910 (292)
Factors Influencing the Binding of HIV‐1 Protease Inhibitors: Insights from Machine Learning Models
ChemMedChem, EarlyView.Machine learning unlocks the secrets of HIV‐1 protease inhibition, paving the way for data‐driven antiviral drug design. This study analyzes crystallographic data from hundreds of protein–ligand complexes, predicting ligand binding affinity with over 85% accuracy.
Yaffa Shalit, Inbal Tuvi‐Arad
wiley +1 more source
Draft Genome Sequence of Mycobacterium heckeshornense Strain RLE. [PDF]
, 2015 We report here the draft genome sequence of Mycobacterium heckeshornense strain RLE isolated from a sputum sample from a patient with shortness of breath.
Chiu, Charles Y +3 more
core +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months regimens were simulated using a population pharmacokinetic (PPK) model.
Kelong Han +3 more
wiley +1 more source
Glia, EarlyView.Pre‐exposure prophylaxis (PrEP) inhibits oligodendrocyte differentiation. PrEP inhibits oligodendrocyte differentiation through lysosome deacidification. Acidic nanoparticles prevent PrEP‐induced inhibition of oligodendrocyte differentiation. ABSTRACT A disproportionate percentage of adolescents are diagnosed with human immunodeficiency virus (HIV) in ...
Caela C. Long +6 more
wiley +1 more source
Novel prokaryotic system employing previously unknown nucleic acids-based receptors
Microbial Cell Factories, 2022 The present study describes a previously unknown universal system that orchestrates the interaction of bacteria with the environment, named the Teazeled receptor system (TR-system). The identical system was recently discovered within eukaryotes.
Victor Tetz, George Tetz
doaj +1 more source
Recombination directionality factor gp3 binds ϕC31 integrase via the zinc domain, potentially affecting the trajectory of the coiled-coil motif [PDF]
, 2017 To establish a prophage state, the genomic DNA of temperate bacteriophages normally becomes integrated into the genome of their host bacterium by integrase-mediated, site-specific DNA recombination.
Fernando, Booshini D +5 more
core +2 more sources
Multifunctional facets of retrovirus integrase
World Journal of Biological Chemistry, 2015 The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends.
Sibes Bera +3 more
openaire +3 more sources
Interdisciplinary Medicine, EarlyView.Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu +7 more
wiley +1 more source
Draft Genome Sequence of Mycobacterium arupense Strain GUC1. [PDF]
, 2015 We report the draft genome sequence of Mycobacterium arupense strain GUC1 from a sputum sample of a patient with bronchiectasis.
Chiu, Charles Y +5 more
core +2 more sources
The Journal of Clinical Pharmacology, EarlyView.Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora +4 more
wiley +1 more source