Journal of the International AIDS Society, Volume 28, Issue 4, April 2025.Abstract Introduction We assessed the long‐term HIV‐related health outcomes of young adults with perinatally acquired HIV (PHIV) compared with those who acquired HIV through sexual transmission in the Asia‐Pacific region. Methods We conducted a cross‐sectional study using data from three paediatric and adult cohorts within the International ...
Phatharajit Phatharodom +15 more
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Conserved residues Pro-109 and Asp-116 are required for interaction of the human immunodeficiency virus type 1 integrase protein with its viral DNA substrate [PDF]
, 1993 Meera Drelich, Markus Haenggi, Jan Mous
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Phenotypic Characterization of Replication‐Impaired Lenacapavir‐Resistant HIV Clinical Isolates
Journal of Medical Virology, Volume 97, Issue 4, April 2025.ABSTRACT Lenacapavir (LEN) is a potent, first‐in‐class long‐acting HIV‐1 capsid (CA) inhibitor, approved for treatment of people with multi‐drug resistant HIV in combination with other antiretrovirals. In clinical studies with LEN, the CA resistance‐associated mutations (RAMs) M66I, Q67H/K/N, K70H/N/R/S, N74D/H/K, A105S/T, and T107A/C/N/S were observed.
Sally Demirdjian +4 more
wiley +1 more source
Major antigenic region on the integrase (IN) protein of human immunodeficiency virus type 1 determined by reactivity of human sera and a monoclonal antibody to IN protein [PDF]
, 1994 Y Tachibana +5 more
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The Peptide PROTAC Modality: A New Strategy for Drug Discovery
MedComm, Volume 6, Issue 4, April 2025.Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley +1 more source
The Bacteroides mobilizable insertion element, NBU1, integrates into the 3' end of a Leu-tRNA gene and has an integrase that is a member of the lambda integrase family [PDF]
, 1996 Nadja B. Shoemaker +2 more
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AURKA/PLK1/CDC25C Axis as a Novel Therapeutic Target in INI1‐Deficient Epithelioid Sarcoma
Cancer Science, Volume 116, Issue 4, Page 976-989, April 2025.This study confirmed that reintroducing INI1 in epithelioid sarcoma (EpS) markedly reduced cell proliferation, eradicated tumorigenicity, and downregulated AURKA and its downstream effectors, including PLK1 and CDC25C. Additionally, alisertib, a selective AURKA inhibitor, induced G2/M cell cycle arrest and apoptosis in EpS cells by inactivating AURKA's
Akitomo Inoue +7 more
wiley +1 more source
The core domain of retrotransposon integrase in Hordeum: predicted structure and evolution [PDF]
, 1998 A. Suoniemi +4 more
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Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders
Cell Proliferation, Volume 58, Issue 4, April 2025.This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
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Point‐of‐care nucleic acid testing – a step forward in controlling the HIV epidemic: A review
HIV Medicine, Volume 26, Issue 4, Page 536-545, April 2025.Abstract Introduction The HIV/AIDS epidemic, with 85.6 million infections and 40.4 million AIDS‐related deaths globally, remains a critical public health challenge. Current diagnostic methods, primarily fourth‐generation immunoassays, have limitations due to their long window periods, and most viral load assays require centralized testing protocols ...
Suleyman Sarp Pinar +4 more
wiley +1 more source