Results 111 to 120 of about 18,910 (292)
Draft Genome Sequence of Mycobacterium elephantis Strain Lipa. [PDF]
, 2015 We report the draft genome sequence of Mycobacterium elephantis strain Lipa from a sputum sample of a patient with pulmonary disease. This is the first draft genome sequence of M.
Chiu, Charles Y +5 more
core +1 more source
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
VIEW, EarlyView.Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma +6 more
wiley +1 more source
HUH site-specific recombinases for targeted modification of the human genome [PDF]
, 2016 Site-specific recombinases (SSRs) have been crucial in the development of mammalian transgenesis. For gene therapy purposes, this approach remains challenging, because, for example, SSR delivery is largely unresolved and SSR DNA substrates must pre-exist
Agúndez, Leticia +3 more
core +1 more source
Andrology, EarlyView.Abstract Background Erectile dysfunction in people living with HIV is a multifactorial disease, but the role of penile vascular status assessed by dynamic penile color Doppler echography is underexplored. Objectives This study assessed penile vascular status in young males living with HIV experiencing erectile dysfunction, comparing them to HIV ...
Giorgio Tiecco +9 more
wiley +1 more source
Australian Veterinary Journal, EarlyView.Progressive feline leukaemia virus (FeLV) infection dramatically shortens the lives of infected cats, causing acquired immunodeficiency, aplastic anaemia, lymphoma, leukaemia and other myeloproliferative diseases. The potential impact of regressive FeLV infection on the development of disease remains largely unknown, although there is evidence it ...
ME Westman +6 more
wiley +1 more source
The site-specific integration reaction of
Mobile DNA, 2013 Background A large subfamily of serine recombinases contains long polypeptide segments appended to the C-terminal end of the conserved catalytic domain.
Mandali Sridhar +4 more
doaj +1 more source
Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads
Molecular Systems Biology, 2020 Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically stable and not hinder the host. Encoding circuits in the genome reduces burden, but this decreases
Yongjin Park +4 more
doaj +1 more source
Draft Genome Sequence of Mycobacterium heraklionense Strain Davo. [PDF]
, 2015 We report the draft genome sequence of Mycobacterium heraklionense strain Davo, isolated from a fine-needle aspirate of a right-ankle soft-tissue mass. This is the first draft genome sequence of Mycobacterium heraklionense, a nonpigmented rapidly growing
Chiu, Charles Y +3 more
core +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Quantitative Modeling of Integrase Dynamics Using a Novel Python Toolbox for Parameter Inference in Synthetic Biology [PDF]
, 2017 The recent abundance of high-throughput data for biological circuits enables data-driven quantitative modeling and parameter estimation. Common modeling issues include long computational times during parameter estimation, and the need for many iterations
Hsiao, Victoria +2 more
core +1 more source