Results 121 to 130 of about 18,910 (292)

HIV Dynamics and Integrase Inhibitors

Antiviral Chemistry and Chemotherapy, 2009
The integrase inhibitor (INI) raltegravir has shown promising results in clinical trials to date, reducing second phase HIV RNA levels by 70% in comparison with standard regimens. These trial results have been limited by the 50 copies/ml detection limit of the HIV RNA assay and have not investigated the effect of an INI regimen on levels of latently ...
openaire   +3 more sources

Metabolic syndrome and Pathobiological Determination of Atherosclerosis in Youth risk score in adolescents with and without perinatally acquired HIV in the Cape Town Adolescent and Antiretroviral Cohort (CTAAC)‐Heart study

HIV Medicine, EarlyView.
Abstract Background Limited data exist describing metabolic syndrome (MetS) and Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary arteries (CA) and abdominal aorta (AA) risk scores in youth with HIV in sub‐Saharan Africa.
Sahera Dirajlal‐Fargo, Mothabisi Nyathi, Shan Sun, Lauren Balmert Bonner, Morné Kahts, Nana Akua Asafu‐Agyei, Nomawethu Jele, Emma Carkeek, Justine Legbedze, Grace A. McComsey, Matthew Feinstein, Landon Myer, Ntobeko A. B. Ntusi, Heather J. Zar, Jennifer Jao   +14 more
wiley   +1 more source

Proof of concept continuous event logging in living cells [PDF]

, 2017
Cells must detect and respond to molecular events such as the presence or absence of specific small molecules. To accomplish this, cells have evolved methods to measure the presence and concentration of these small molecules in their environment and ...
Murray, Richard M., Shur, Andrey
core   +1 more source

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

eLife, 2019
ABSTRACTA large number of HIV-1 integrase (IN) alterations, referred to as class II substitutions, exhibit pleotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of three distinct ...
Elliott, Jennifer, Eschbach, Jenna E., Koneru, Pratibha C., Li, Wen, Chavez, Maritza Puray, Townsend, Dana, Lawson, Dana, Engelman, Alan N., Kvaratskhelia, Mamuka, Kutluay, Sebla B.   +9 more
openaire   +6 more sources

Comparison of treatment‐emergent resistance‐associated mutations and discontinuation due to adverse events among integrase strand transfer inhibitor‐based single‐tablet regimens and cabotegravir + rilpivirine for the treatment of virologically suppressed people with HIV: A systematic literature review and network meta‐analysis

HIV Medicine, EarlyView.
Abstract Objective This study evaluated rates of treatment‐emergent resistance‐associated mutations (TE‐RAMs) and discontinuation due to adverse events (DC‐AEs) across integrase strand transfer inhibitor (INSTI)‐based single‐tablet regimens and injectable cabotegravir + rilpivirine (CAB + RPV) in virologically suppressed people with HIV.
Ishfaq Rashid, Nathan R. Unger, Connor Willis, Teerapon Dhippayom, Moti Ramgopal, Elizabeth M. Sherman, Nicholas Yared, Rachel Safran, Edwin Swiatlo, Amy R. Weinberg, Soodi Navadeh, Howard Weston Schmutz, Nathorn Chaiyakunapruk   +12 more
wiley   +1 more source

Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection.

PLoS ONE, 2019
Eukaryotic DNA binding proteins must access genomic DNA that is packaged into chromatin in vivo. During a productive infection, retroviral integrases (IN) must similarly interact with chromatin to integrate the viral cDNA genome. Here we examine the role
Randi M Mackler, Nathan D Jones, Anne M Gardner, Miguel A Lopez, Cecil J Howard, Richard Fishel, Kristine E Yoder   +6 more
doaj   +1 more source

Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination [PDF]

, 2013
Synthetic biology requires effective methods to assemble DNA parts into devices and to modify these devices once made. Here we demonstrate a convenient rapid procedure for DNA fragment assembly using site-specific recombination by ϕC31 integrase.
Colloms, S.D., Keasling, J.D., Merrick, C.A., Olorunniji, F.J., Osbourn, A., Rosser, S.J., Smith, M.C.M., Stark, W.M.   +7 more
core   +4 more sources

Willingness to participate in clinical trials and expectations towards antiretroviral therapy among heavily treatment‐experienced people living with HIV: A feasibility survey

HIV Medicine, EarlyView.
Abstract Introduction As life expectancy among persons with HIV on antiretroviral therapy (ART) is increasing, comorbidities and polypharmacy increase. Drug–drug interactions (DDIs) are common among persons with HIV with a history of virological failure, since many are receiving boosted ART.
Marie Ballif, Manuela Correia da Silva Saúde, David Haerry, Marcel Stoeckle, Patrick Schmid, Dominique Braun, Alexandra Calmy, Gilles Wandeler, Bernard Surial   +8 more
wiley   +1 more source

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction [PDF]

, 2016
The bromodomain and extraterminal domain (BET) protein family are promising therapeutic targets for a range of diseases linked to transcriptional activation, cancer, viral latency, and viral integration.
Crowe, Brandon L., Foster, Mark P., Hess, Sonja, Kvaratskhelia, Mamuka, Larue, Ross C., Yuan, Chunhua   +5 more
core   +2 more sources

Characterization of the cryptic lambdoid prophage DLP12 of Escherichia coli and overlap of the DLP12 integrase gene with the tRNA gene argU [PDF]

, 1989
David F. Lindsey, D A Mullin, James R. Walker   +2 more
openalex   +1 more source