Results 41 to 50 of about 18,910 (292)
Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis [PDF]
Heliyon, 2018 Integrase (IN) plays an essential role in HIV-1 replication, by mediating integration of the viral genome into the host cell genome. IN is a potential target of antiretroviral (ARV) therapeutic drugs such as ALLINI, Raltegravir (RAL), and Elvitegravir (EVG).
Hotma Martogi Lorensi Hutapea +2 more
openaire +4 more sources
Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict [PDF]
, 2016 Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial.
A Adams +157 more
core +3 more sources
The SSV1 viral integrase is not essential
Virology, 2007 Viral integration is a widely conserved characteristic in viruses in all domains of life; however, its necessity is not well understood in many cases. Integration using tyrosine recombinases is one of the most widespread and best characterized mechanisms of integration. We completely removed the tyrosine recombinase integrase from the hyperthermophilic
Adam J. Clore, Kenneth M. Stedman
openaire +3 more sources
Integrating vectors for genetic studies in the rare Actinomycete Amycolatopsis marina
BMC Biotechnology, 2019 Background Few natural product pathways from rare Actinomycetes have been studied due to the difficulty in applying molecular approaches in these genetically intractable organisms.
Hong Gao +5 more
doaj +1 more source
Influence of the amino-terminal sequence on the structure and function of HIV integrase
Retrovirology, 2020 Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical data on targets and their responses
Grant Eilers +7 more
doaj +1 more source
Transcriptome analysis of bacteriophage communities in periodontal health and disease. [PDF]
, 2015 BackgroundThe role of viruses as members of the human microbiome has gained broader attention with the discovery that human body surfaces are inhabited by sizeable viral communities.
Abeles, Shira R +5 more
core +2 more sources
Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]
, 2013 Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Best, AA +17 more
core +4 more sources
Lambda Integrase: Armed for Recombination [PDF]
Current Biology, 2005 Bacteriophage lambda moves its viral genome into and out of the bacterial chromosome using site-specific recombination. Crystal structures of reaction intermediates in this recombination pathway provide exciting new snapshots of full length lambda integrase interacting with both core and regulatory DNA elements.
openaire +3 more sources
PLoS Pathogens, 2023 Transmissions of simian viruses to humans has originated the different groups of HIV-1. We recently identified a functional motif (CLA), in the C-terminal domain of the integrase, essential for integration in HIV-1 group M.
Elenia Toccafondi +4 more
doaj +2 more sources
Application of serine integrases for secondary metabolite pathway assembly in Streptomyces
Synthetic and Systems Biotechnology, 2020 Serine integrases have been shown to be efficient tools for metabolic pathway assembly. To further improve the flexibility and efficiency of pathway engineering via serine integrases, we explored how multiple orthogonally active serine integrases can be ...
Hong Gao +4 more
doaj