Results 41 to 50 of about 13,949 (234)
Integrating vectors for genetic studies in the rare Actinomycete Amycolatopsis marina
BMC Biotechnology, 2019 Background Few natural product pathways from rare Actinomycetes have been studied due to the difficulty in applying molecular approaches in these genetically intractable organisms.
Hong Gao +5 more
doaj +1 more source
PLoS Pathogens, 2023 Transmissions of simian viruses to humans has originated the different groups of HIV-1. We recently identified a functional motif (CLA), in the C-terminal domain of the integrase, essential for integration in HIV-1 group M.
Elenia Toccafondi +4 more
doaj +2 more sources
Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
Nature Communications, 2019 Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into ...
Marcus D. Wilson +8 more
doaj +1 more source
Influence of the amino-terminal sequence on the structure and function of HIV integrase
Retrovirology, 2020 Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical data on targets and their responses
Grant Eilers +7 more
doaj +1 more source
Environmental Microbiome, 2022 Background Wastewater treatment plants are an essential part of maintaining the health and safety of the general public. However, they are also an anthropogenic source of antibiotic resistance genes.
Paul Jankowski +7 more
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Lambda Integrase: Armed for Recombination [PDF]
Current Biology, 2005 Bacteriophage lambda moves its viral genome into and out of the bacterial chromosome using site-specific recombination. Crystal structures of reaction intermediates in this recombination pathway provide exciting new snapshots of full length lambda integrase interacting with both core and regulatory DNA elements.
openaire +3 more sources
Application of serine integrases for secondary metabolite pathway assembly in Streptomyces
Synthetic and Systems Biotechnology, 2020 Serine integrases have been shown to be efficient tools for metabolic pathway assembly. To further improve the flexibility and efficiency of pathway engineering via serine integrases, we explored how multiple orthogonally active serine integrases can be ...
Hong Gao +4 more
doaj
Tangle Solutions for a Family of DNA-Rearranging Proteins [PDF]
, 2004 We study two systems of tangle equations that arise when modeling the action of the Integrase family of proteins on DNA. These two systems--direct and inverted repeats--correspond to two different possibilities for the initial DNA sequence. We present one new class of solutions to the tangle equations.
arxiv +1 more source
Pharmaceutics, 2022 Phages are naturally occurring viruses that selectively kill bacterial species without disturbing the individual’s normal flora, averting the collateral damage of antimicrobial usage.
Lynn El Haddad +11 more
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Bacterial transposases and retroviral integrases [PDF]
Molecular Microbiology, 1995 SummaryTransposable genetic elements have adopted two major strategies for their displacement from one site to another within and between genomes. One involves passage through an RNA intermediate prior to synthesis of a DNA copy while the other is limited uniquely to DNA intermediates.
Michael Chandler, Patrice Polard
openaire +3 more sources