Results 51 to 60 of about 18,910 (292)
Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
Nature Communications, 2019 Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into ...
Marcus D. Wilson +8 more
doaj +1 more source
Unraveling the genomic mosaic of a ubiquitous genus of marine cyanobacteria [PDF]
, 2008 Background: The picocyanobacterial genus Synechococcus occurs over wide oceanic expanses, having colonized most available niches in the photic zone. Large scale distribution patterns of the different Synechococcus clades (based on 16S rRNA gene markers)
de Marsac, Nicole Tandeau +14 more
core +5 more sources
Environmental Microbiome, 2022 Background Wastewater treatment plants are an essential part of maintaining the health and safety of the general public. However, they are also an anthropogenic source of antibiotic resistance genes.
Paul Jankowski +7 more
doaj +1 more source
Bacterial transposases and retroviral integrases [PDF]
Molecular Microbiology, 1995 SummaryTransposable genetic elements have adopted two major strategies for their displacement from one site to another within and between genomes. One involves passage through an RNA intermediate prior to synthesis of a DNA copy while the other is limited uniquely to DNA intermediates.
Michael Chandler, Patrice Polard
openaire +3 more sources
Genome integration and excision by a new Streptomyces bacteriophage, ϕJoe [PDF]
, 2017 Bacteriophages are the source of many valuable tools for molecular biology and genetic manipulation. In Streptomyces, most DNA cloning vectors are based on serine integrase site-specific DNA recombination systems derived from phage.
Fogg, Paul C M +3 more
core +2 more sources
Mechanistic modelling of a recombinase-based two-input temporal logic gate [PDF]
, 2017 Site-specific recombinases (SSRs) mediate efficient manipulation of DNA sequences in vitro and in vivo. In particular, serine integrases have been identified as highly effective tools for facilitating DNA inversion, enabling the design of genetic ...
Bates, Declan +3 more
core +1 more source
Pharmaceutics, 2022 Phages are naturally occurring viruses that selectively kill bacterial species without disturbing the individual’s normal flora, averting the collateral damage of antimicrobial usage.
Lynn El Haddad +11 more
doaj +1 more source
The role of single occupancy effects on integrase dynamics in a cell-free system [PDF]
, 2016 Phage integrase-based circuits are an alternative approach to relying on transcriptional and translational repression for biomolecular circuits. Previous research has shown that circuits based on integrases can perform a variety of functions, including ...
Artavanis, Georgios +3 more
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani +11 more
wiley +1 more source
Multiple choices for HIV therapy with integrase strand transfer inhibitors
Retrovirology, 2012 Two integrases inhibitors, raltegravir and elvitegravir, have now been approved by regulatory agencies for use in the treatment of HIV-infected patients; and the approval of a third such drug, dolutegravir, is expected during 2013 on the basis of several
Raffi Francois, Wainberg Mark A
doaj +1 more source