Results 71 to 80 of about 18,910 (292)
Repressing Integrase attachment site operation with CRISPR-Cas9 in E. coli [PDF]
, 2017 Serine integrases are bacteriophage proteins responsible for integrating the phage genome into that of the host. Synthetic biologists have co-opted these proteins into useful tools for permanent DNA logic, utilizing their specific DNA recombination ...
Murray, Richard M., Shur, Andrey
core +1 more source
Advanced Science, EarlyView.In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang +11 more
wiley +1 more source
Mobile DNA, 2010 Background In eukaryotes, long terminal repeat (LTR) retrotransposons such as Copia, BEL and Gypsy integrate their DNA copies into the host genome using a particular type of DDE transposase called integrase (INT).
Bao Weidong +2 more
doaj +1 more source
Frontiers in Microbiology, 2022 Salmonella enterica serovar Indiana (S. Indiana) has aroused widespread concern as an important zoonotic pathogen. The molecular mechanism of multidrug resistance (MDR) in S. Indiana is not known and should be assessed.
Xuefeng Wang +6 more
doaj +1 more source
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography [PDF]
, 2007 Soil bacteria that also form mutualistic symbioses in plants encounter two major levels of selection. One occurs during adaptation to and survival in soil, and the other occurs in concert with host plant speciation and adaptation. Actinobacteria from the
Alloisio, Nicole +19 more
core +2 more sources
Brujita Integrase: A Simple, Arm-Less, Directionless, and Promiscuous Tyrosine Integrase System [PDF]
Journal of Molecular Biology, 2016 Mycobacteriophage Brujita is an unusual temperate phage in which establishment of superinfection immunity is dependent on chromosomal integration. Integration is mediated by a non-canonical tyrosine integrase (Int) lacking an N-terminal domain typically associated with binding to arm-type sites within the phage attachment site (attP).
Bryce L. Lunt, Graham F. Hatfull
openaire +3 more sources
Advanced Science, EarlyView.This study illustrates the impact of viruses on carbon cycling in soils with different availabilities of carbon. In conditions of low carbon availability, viruses adopt a lysogenic lifestyle, integrate into the host genomes and facilitate the degradation of carbon.
Mingfeng Liu +8 more
wiley +1 more source
Control of serine integrase recombination directionality by fusion with the directionality factor [PDF]
, 2017 Bacteriophage serine integrases are extensively used in biotechnology and synthetic biology for assembly and rearrangement of DNA sequences. Serine integrases promote recombination between two different DNA sites, attP and attB, to form recombinant attL ...
Akopian +43 more
core +3 more sources
A Drosophila model of prion disease and its metabolic changes in the brain
Animal Models and Experimental Medicine, EarlyView.We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang +14 more
wiley +1 more source