Results 81 to 90 of about 18,910 (292)

Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2010
Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined.We identified 29 individuals who exhibited evidence of incomplete viral suppression on a regimen containing an integrase
Wei Huang, Christos J. Petropoulos, Hiroyu Hatano, Harry Lampiris, Harry Lampiris, Signe Fransen, David R. Bangsberg, Jeffrey N. Martin, Rebecca Hoh, Soumi Gupta, Jacob Lalezari, Steven G. Deeks   +11 more
openaire   +3 more sources

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

Filamentous phages of Ralstonia solanacearum: Double-edged swords for pathogenic bacteria

Frontiers in Microbiology, 2013
Some phages from genus Inovirus use host or bacteriophage-encoded site-specific integrases or recimbinases establish a prophage state. During integration or excision, a superinfective form can be produced.
Takashi eYamada
doaj   +1 more source

Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors

Journal of Global Antimicrobial Resistance, 2020
This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this drug class.The emergence of INSTI-RMs and integrase evolution (estimated as genetic distance between integrase ...
Scutari, Rossana, Alteri, Claudia, Vicenti, Ilaria, Carlo, Domenico Di, Zuccaro, Valentina, Incardona, Francesca, Borghi, Vanni, Bezenchek, Antonia, Andreoni, Massimo, Antinori, Andrea, Perno, Carlo Federico, Cascio, Antonio, De Luca, Andrea, Zazzi, Maurizio, Santoro, Maria Mercedes   +14 more
openaire   +9 more sources

Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei, Chunliu Huang, Zenghua Zhou, Yanni Lan   +3 more
wiley   +1 more source

A mathematical model of bacteria capable of complete oxidation of ammonium predicts improved nitrogen removal and reduced production of nitrous oxide [PDF]

, 2017
The removal of excess nutrients from water ecosystems requires oxidation of toxic ammonium by two types of bacteria; one oxidizes ammonium to nitrite and the other oxidizes nitrite to nitrate.
Ebenhöh, Oliver, Pokhilko, Alexandra
core  

HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants

Antimicrobial Agents and Chemotherapy, 2020
The currently recommended first-line therapy for HIV-1-infected patients is an integrase (IN) strand transfer inhibitor (INSTI), either dolutegravir (DTG) or bictegravir (BIC), in combination with two nucleoside reverse transcriptase inhibitors (NRTIs). Both DTG and BIC potently inhibit most INSTI-resistant IN mutants selected by the INSTIs raltegravir
Stephen H. Hughes, Dmitry Lyumkis, Dmitry Lyumkis, Xue Zhi Zhao, Dario O. Passos, Terrence R. Burke, Steven J. Smith   +6 more
openaire   +3 more sources

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.

PLoS ONE, 2013
PWWP domains are involved in the chromatin attachment of several proteins. They bind to both DNA and proteins and their interaction with specific histone methylation marks define them as a new class of histone code readers.
Mehdi Morchikh, Monica Naughtin, Francesca Di Nunzio, Johan Xavier, Pierre Charneau, Yves Jacob, Marc Lavigne   +6 more
doaj   +1 more source

The influence of the accessory genome on bacterial pathogen evolution [PDF]

, 2011
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity.
Abu-Ali GS, Adiba S, Alfano JR, Arnold DL, Arnold DL, Arnold DL, Asadulghani M, Baharoglu Z, Baquero F, Barash I, Blondel CJ, Blondel CJ, Brüssow H, Cambray G, Chen J, Chen Y, Choi J, Colinon C, Croucher NJ, Dawes FE, De Gelder L, Diard M, Dillon SC, Douard G, Doyle M, Elsaied H, Fondi M, Freeman VJ, Gartemann KH, Gillings MR, Godfrey SAC, Govind R, Greenberg JT, Grillot-Courvalin C, Groisman EA, Guerin E, Hacker J, Hacker J, Halary S, Hassan F, Hazen TH, Hegstad K, Heinemann JA, Heringa S, Hochhut B, Holden MT, Huang L, Imamovic L, Jackson RW, Jackson RW, Jenner C, Joss M, Jové T, Kearney B, Kers JA, Kiiru JN, Koenig JE, Koenig JE, Krauland MG, Landgraf A, Larsson P, Leplae Rl, León G, Lipps HJ, Lloyd AL, Loftie-Eaton W, Lovell HC, Lovell HC, Manning SD, Marchetti M, Matz C, Maurelli AT, Mazel D, Michael CA, Michael CA, Morris CE, Morris CE, Moura A, Naas T, Nadarasah G, Naka H, Nawaz M, Ogura Y, Paauw A, Partridge SR, Pitman A, Poirel L, Poirel L, Ramirez MS, Rankin DJ, Rezzonico F, Rivas LA, Rodriguez-Martinez JM, Rohmer L, Rosewarne CP, Sajjad A, Salanoubat M, Salzberg SL, Seth-Smith H, Shaheen BW, Siguier P, Siguier P, Smillie C, Smith AB, Song H, Sota M, Steinberg KM, Sundin GW, Sundin GW, Tao L, Treangen TJ, van der Meer JR, van der Veen EL, van Essen-Zandbergen A, Wagner A, Waldor MK, Wiesner M, Woodford N, Yang H, Zhou Z, Zupan J   +120 more
core   +2 more sources