Results 81 to 90 of about 14,447 (191)
Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim +4 more
wiley +1 more source
Bee products as alternatives in the treatment of viral infections
Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba +3 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood‐based biomarkers offer a promising diagnostic alternative.
Akarin Hiransuthikul +9 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Long‐acting cabotegravir is approved for HIV treatment and prevention. To guide management of dosing deviations and interruptions, concentration‐time profiles for monthly and every 2 months regimens were simulated using a population pharmacokinetic (PPK) model.
Kelong Han +3 more
wiley +1 more source
Novel Mobile Integrons and Strain-Specific Integrase Genes within Shewanella spp. Unveil Multiple Lateral Genetic Transfer Events within The Genus [PDF]
, 2022 Teolincacihuatl Ayala Nuñez +4 more
openalex +1 more source
Journal of Basic Microbiology, Volume 66, Issue 1, January 2026.ABSTRACT Mycobacteriophage Mcgavigan could be a promising candidate for use as a preventative agent against infections with Mycobacterium avium subsp. paratuberculosis. Bioinformatic analysis of the Mcgavigan genome revealed the presence of an operon containing a “Bxb1‐like” repressor.
Natali Shafer +2 more
wiley +1 more source
Engineering CRISPR for emerging therapeutic applications
EngMedicineClustered regularly interspaced short palindromic repeats (CRISPRs) were originally identified in bacterial and archaeal genomes as an adaptive immune response against invading viruses and phages.
Xiaoqi Sun, Zhuang Liu
doaj +1 more source
Divergent Evolution and Local Establishment of Multidrug‐Resistant Shigella sonnei in China
MedComm, Volume 7, Issue 1, January 2026.• Evolutionary history and local establishment of Chinese Shigella sonnei are unclear. • Chinese S. sonnei developed into four clades and ONPG‐negative variants. • The antimicrobial resistance phenotype of Clade I was due to an IncB/O/K/Z plasmid. • Antimicrobial resistance of Clade II was due to IncFII and IncB/O/K/Z plasmids.
Kangkang Liu +26 more
wiley +1 more source
CASP16 Protein Monomer Structure Prediction Assessment
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 86-105, January 2026.ABSTRACT The assessment of monomer targets in the Critical Assessment of Structure Prediction Round 16 (CASP16) underscores that the problem of single‐domain protein fold prediction is nearly solved—no target folds were incorrectly predicted across all Evaluation Units.
Rongqing Yuan +6 more
wiley +1 more source
Designing potential HIV-1 integrase inhibitors: An In silico approach
, 2021 Arif Mermer
openalex +2 more sources