Results 81 to 90 of about 13,949 (234)
HIV Medicine, EarlyView.Abstract Objectives Human papillomavirus (HPV)‐associated cervical cancer risk is greater in people with HIV, although this has been at least partially attenuated by antiretroviral medication, enhanced cervical screening and HPV vaccination. People with perinatally acquired HIV may remain at higher risk due to lifelong immunosuppression and potentially
Merle Henderson +12 more
wiley +1 more source
Hamming distance geometry of a protein conformational space. Application to the clustering of a 4 ns molecular dynamics trajectory of the HIV-1 integrase catalytic core [PDF]
PROTEINS: Structure, Function, and Genetics 47, 169-179 (2002), 2001 Protein structures can be encoded into binary sequences, these are used to define a Hamming distance in conformational space: the distance between two different molecular conformations is the number of different bits in their sequences. Each bit in the sequence arises from a partition of conformational space in two halves. Thus, the information encoded
arxiv
HIV Medicine, EarlyView.Abstract Introduction Black and Hispanic/Latine people are disproportionately affected by HIV‐1 and may have a greater risk of comorbidities than non‐Black and non‐Hispanic/Latine people with HIV. However, they have historically been underrepresented in HIV clinical studies.
C. Martorell +14 more
wiley +1 more source
HIV Medicine, EarlyView.Abstract Introduction Integrase strand transfer inhibitors (INSTIs) are the mainstay of treatment in adults and children living with HIV. Weight gain has been associated with INSTI use in adults; however, less data exist on its effects on younger patients.
Kathleen J. Pincus +6 more
wiley +1 more source
mBio, 2020 Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria.
Luchao Lv +16 more
doaj +1 more source
Combining Alchemical Transformation with Physical Pathway to Accurately Compute Absolute Binding Free Energy [PDF]
arXiv, 2018 We present a new method that combines alchemical transformation with physical pathway to accurately and efficiently compute the absolute binding free energy of receptor-ligand complex. Currently, the double decoupling method (DDM) and the potential of mean force approach (PMF) methods are widely used to compute the absolute binding free energy of ...
arxiv
Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health
HIV Medicine, EarlyView.Abstract Purpose HIV outcome changed drastically with antiretroviral (ARV) therapy, especially after the introduction of second‐generation integrase strand transfer inhibitors (INSTIs). Despite these advances, however, chronic immune activation and exhaustion, marked by programmed cell death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) upregulation ...
Bogusz Aksak‐Wąs +8 more
wiley +1 more source
Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal
eLife, 2017 The transposition of bacteriophage Mu serves as a model system for understanding DDE transposases and integrases. All available structures of these enzymes at the end of the transposition reaction, including Mu, exhibit significant bends in the ...
James R Fuller, Phoebe A Rice
doaj +1 more source
The Molecular Biology of HIV Integrase [PDF]
Future Virology, 2012 Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that catalyzes DNA integration, have recently been approved and more are in the pipeline. These drugs bind to an intermediate in DNA integration called the intasome, in
openaire +3 more sources
HIV Medicine, EarlyView.Abstract Objectives This retrospective, observational, non‐interventional study describes the demographics, characteristics, immunological and virological status, coinfections, healthcare unit of HIV diagnosis and follow‐up status of Ukrainian refugees with newly diagnosed HIV in the Czech Republic, with a special focus on those with a late HIV ...
Zofia Bartovská +20 more
wiley +1 more source