Results 121 to 130 of about 167,996,906 (262)

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread

, 2020
Listeria monocytogenes is a human bacterial pathogen that disseminates through host tissues using a process called cell-to-cell spread. This critical yet understudied virulence strategy resembles a vesicular form of intercellular trafficking that allows ...
Sanderlin, Allen G, Ahyong, Vida, Vondrak, Cassandra, Fedrigo, Indro, Scricco, Arianna J., Lamason, Rebecca L.   +5 more
core   +1 more source

Single-nucleus transcriptomics reveal cardiac cell type-specific diversification in metabolic disease transgenic pigs

iScience
Summary: Cardiac damage is widely present in patients with metabolic diseases, but the exact pathophysiological mechanisms involved remain unclear. The porcine heart is an ideal material for cardiovascular research due to its similarities to the human ...
Jiakun Miao, Kaiyi Zhang, Yu Yang, Shuang Xu, Juan Du, Tianwen Wu, Cong Tao, Yanfang Wang, Shulin Yang   +8 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena

, 2015
During breast cancer progression, alternative mRNA splicing produces functionally distinct isoforms of Mena, an actin regulator with roles in cell migration and metastasis.
Lussiez, Alisha, Joughin, Brian A., White, Forest M., Del Rosario, Amanda, Condeelis, John S, van Rheenen, Jacco, Oudin, Madeleine J, Oudin, Madeleine Julie, Vasile, Eliza, Hughes, Shannon K, Neil, Jason, Eddy, Robert, Condeelis, John S., Philippar, Ulrike, Lauffenburger, Douglas A, Gertler, Frank B, Hughes, Shannon Kay, Wyckoff, Jeff, Gertler, Frank, Tadros, Jenny, Neil, Jason Robert, Joughin, Brian A, Ritsma, Laila, White, Forest, Lauffenburger, Douglas A., Del Rosario, Amanda M.   +25 more
core   +1 more source

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

iScience
Summary: Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury (ALI) is poorly understood.
Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie Yang   +9 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A mechanistic computational model of HGF-VEGF-mediated endothelial cell proliferation and vascular permeability

iScience
Summary: Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) are important pro-angiogenic factors in angiogenesis-dependent diseases.
Rebeca Hannah de Melo Oliveira, Akash Patil, Brian H. Annex, Arvind P. Pathak, Aleksander S. Popel   +4 more
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source