Results 101 to 110 of about 145,713 (206)

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

iScience
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung.
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick   +4 more
doaj   +1 more source

Probabilistic methods in the analysis of protein interaction networks [PDF]

, 2010
Imperial Users ...
Thorne, Thomas, Thorne, Thomas
core  

A population model reveals a surprising role of stochastic cell division in epigenetic memory systems

iScience
Summary: Epigenetic memory systems store transient environmental signals in bacteria in specific DNA methylation patterns. Synthetic zinc finger protein (ZnF4) binds to the DNA in a methylation-dependent manner and represses the expression of the DNA ...
Viviane Klingel, Dimitri Graf, Sara Weirich, Albert Jeltsch, Nicole E. Radde   +4 more
doaj   +1 more source

Single-cell transcriptomic reveals the peritoneal microenvironmental change in long-term peritoneal dialysis patients with ultrafiltration failure

iScience
Summary: The microenvironmental changes in peritoneal dialysis effluent (PDE) after long-term vintage (LV) of PD in patients with ultrafiltration failure (LV_UF) are unclear.
Xiangwen Diao, Cuixia Zhan, Hongjian Ye, Haishan Wu, Chunyan Yi, Jianxiong Lin, Haiping Mao, Wei Chen, Xiao Yang   +8 more
doaj   +1 more source

Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

iScience
Summary: Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension.
Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F. Baumert, Joachim Lupberger, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Eric Simon, André F. Rendeiro, Laura P.M.H. de Rooij, Philipp Schwabl, Thomas Reiberger   +16 more
doaj   +1 more source

A multiscale model for collagen alignment in wound healing [PDF]

, 2005
It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving
Dallon, J. C., Maini, P. K., Sherratt, J. A.   +2 more
core   +1 more source

How was it for you? A cross-disciplinary study of ‘troublesome knowledge’ as identified by undergraduate students and lecturers in Geography, Medical Science and Psychology [PDF]

, 2011
We carried out a small scale pilot study to determine whether participants would spontaneously identify Threshold Concepts (TC’s) and/or troublesome knowledge during open questioning on the characteristics of their disciplines.
Jamieson, Susan, MacAndrew, Siobhan B. G., Spedding, Nicholas   +2 more
core  

Single-nucleus transcriptomics reveal cardiac cell type-specific diversification in metabolic disease transgenic pigs

iScience
Summary: Cardiac damage is widely present in patients with metabolic diseases, but the exact pathophysiological mechanisms involved remain unclear. The porcine heart is an ideal material for cardiovascular research due to its similarities to the human ...
Jiakun Miao, Kaiyi Zhang, Yu Yang, Shuang Xu, Juan Du, Tianwen Wu, Cong Tao, Yanfang Wang, Shulin Yang   +8 more
doaj   +1 more source

Cancer modelling: Getting to the heart of the problem [PDF]

, 2005
Paradoxically, improvements in healthcare that have enhanced the life expectancy of humans in the Western world have, indirectly, increased the prevalence of certain types of cancer such as prostate and breast.
Alarcon, T., Byrne, H. M., Maini, P. K.
core  

SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

iScience
Summary: Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury (ALI) is poorly understood.
Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie Yang   +9 more
doaj   +1 more source