Results 81 to 90 of about 145,713 (206)

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

, 2019
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different ...
Ales, J., Carrillo-Bustamante, P., Fackler, O., Fehr, J., Godinez, W., Graw, F., Hamprecht, F., Imle, A., Kumberger, P., Müller, B., Ritter, C., Rohr, K., Schmidt, P., Schnellbächer, N., Schwarz, U.   +14 more
core   +2 more sources

Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma

iScience
Summary: Brain metastases (BM) of lung adenocarcinoma (LUAD) are the most common intracranial malignancy leading to death. However, the cellular origins and drivers of BM from LUAD have not been clarified. Cellular composition was characterized by single-
Yonghui Wu, Fujun Yang, Shilan Luo, Xiang Li, Zhan Gu, Rui Fan, Yajuan Cao, Lixin Wang, Xiao Song   +8 more
doaj   +1 more source

Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors

iScience
Summary: Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance.
Eun-Ji Kwon, Hyuk-Jin Cha, Haeseung Lee
doaj   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies [PDF]

, 2009
In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns.
Baker, Ruth E., Maini, P. K., Schnell, S.   +2 more
core   +3 more sources

TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells

iScience
Summary: Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV infection
Yuling Sun, Huidi Yu, Zhihao Zhan, Wei Liu, Penggang Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu   +9 more
doaj   +1 more source

Genome Architecture Mediates Transcriptional Control of Human Myogenic Reprogramming

iScience, 2018
Summary: Genome architecture has emerged as a critical element of transcriptional regulation, although its role in the control of cell identity is not well understood.
Sijia Liu, Haiming Chen, Scott Ronquist, Laura Seaman, Nicholas Ceglia, Walter Meixner, Pin-Yu Chen, Gerald Higgins, Pierre Baldi, Steve Smale, Alfred Hero, Lindsey A. Muir, Indika Rajapakse   +12 more
doaj   +1 more source

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne muscular dystrophy

iScience
Summary: In Duchenne muscular dystrophy (DMD), muscle stem cells’ (MuSCs) regenerative capacities are overwhelmed leading to fibrosis. Whether MuSCs have intrinsic defects or are disrupted by their environment is unclear.
Jimmy Massenet, Michèle Weiss-Gayet, Hina Bandukwala, Wilhelm Bouchereau, Stéphanie Gobert, Mélanie Magnan, Arnaud Hubas, Patrick Nusbaum, Isabelle Desguerre, Cyril Gitiaux, F. Jeffrey Dilworth, Bénédicte Chazaud   +11 more
doaj   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources