Results 91 to 100 of about 145,713 (206)

The transcriptome of early compensatory kidney growth reveals cell and time specific responses

iScience
Summary: Following kidney removal, the remaining kidney enlarges and increases its function. The mechanism and signals driving this compensatory kidney hypertrophy and the enlargement of its constituent kidney cells remains elusive.
Darling M. Rojas-Canales, Soon Wei Wong, Elise J. Tucker, Anthony O. Fedele, Kym McNicholas, Anne-Sophie Mehdorn, Jonathan M. Gleadle   +6 more
doaj   +1 more source

Principles And Practices Fostering Inclusive Excellence: Lessons From The Howard Hughes Medical Institute’s Capstone Institutions [PDF]

, 2016
Best-practices pedagogy in science, technology, engineering, and mathematics (STEM) aims for inclusive excellence that fosters student persistence. This paper describes principles of inclusivity across 11 primarily undergraduate institutions designated ...
Cooke, D. B., III, Davidson, C., Davis, G. K., DiBartolo, P. M., Gregg-Jolly, L., Gross, D., Hertz, P. E., Hibbard, L., Ireland, S. K., Iverson, E., Mader, C., Manduca, C. A., Pai, A., Raps, S., Siwicki, Kathleen King, Swartz, J. E.   +15 more
core   +6 more sources

3D imaging and single-cell analysis reveal cellular heterogeneity of lymphatic valve endothelial cell types

iScience
Summary: Lymphatic vasculature has specialized vessels to support unidirectional interstitial fluid transport and immune surveillance. Although the lymphatic system is a critical actor in skin homeostasis, the spatial organization of the lymphatic ...
Emmanuelle Marchaud, Renaud Morin, Jason S. Iacovoni, Tangra Draia-Nicolau, Aurélie Gomes, Marine Norlund, Pascale Bernes-Lasserre, Jean-Michel Lagarde, Anne-Catherine Prats, Barbara Garmy-Susini, Anne Bouloumie, Anaïs Briot, Florence Tatin   +12 more
doaj   +1 more source

Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli. [PDF]

, 2016
A significant obstacle in training predictive cell models is the lack of integrated data sources. We develop semi-supervised normalization pipelines and perform experimental characterization (growth, transcriptional, proteome) to create Ecomics, a ...
Kim, Minseung, Rai, Navneet, Tagkopoulos, Ilias, Zorraquino, Violeta   +3 more
core   +2 more sources

scRNA-seq reveals the diversity of the developing cardiac cell lineage and molecular players in heart rhythm regulation

iScience
Summary: We utilized scRNA-seq to delineate the diversity of cell types in the zebrafish heart. Transcriptome profiling of over 50,000 cells at 48 and 72 hpf defined at least 18 discrete cell lineages of the developing heart.
Karim Abu Nahia, Agata Sulej, Maciej Migdał, Natalia Ochocka, Richard Ho, Bożena Kamińska, Marcin Zagorski, Cecilia Lanny Winata   +7 more
doaj   +1 more source

A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]

, 2008
Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L., Bryce, Nicole, Estrada, Lourdes, Hinow, Peter, Wang, Shizhen Emily, Weaver, Alissa M., Webb, Glenn F.   +6 more
core   +3 more sources

Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma

iScience
Summary: Genomic studies have identified oncogenic drivers in lung cancer, enabling effective targeted therapies. However, patients who initially respond inevitably experience regrowth.
Yang Tian, Reshmee Bhattacharya, Seungyeul Yoo, Feng Jiang, Eric Park, Genesis Lara Granados, Yudao Shen, Kwang-Su Park, Husnu Umit Kaniskan, Jian Jin, Benjamin D. Hopkins, Jun Zhu, Hideo Watanabe   +12 more
doaj   +1 more source

Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans

iScience, 2019
Summary: The cellular response to hypoxia is crucial to organismal survival, and hypoxia-inducible factors (HIF) are the key mediators of this response. HIF-signaling is central to many human diseases and mediates longevity in the nematode.
Reza Esmaillie, Michael Ignarski, Katrin Bohl, Tim Krüger, Daniyal Ahmad, Lisa Seufert, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Francesca Fabretti   +9 more
doaj   +1 more source

RNA Helicase DDX5 Regulates MicroRNA Expression and Contributes to Cytoskeletal Reorganization in Basal Breast Cancer Cells*

Molecular & Cellular Proteomics, 2011
RNA helicase DDX5 (also p68) is involved in all aspects of RNA metabolism and serves as a transcriptional coregulator, but its functional role in breast cancer remains elusive.
Daojing Wang, Jing Huang, Zhi Hu
semanticscholar   +1 more source

Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

iScience
Summary: Humoral factors that prompt fibroblasts to migrate to an injury site at an appropriate time point are deemed indispensable for repair after kidney injury.
Tomohiro Nakata, Yuhei Kirita, Minato Umehara, Masashi Nakamura, Shinji Sawai, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Kunihiro Nakai, Aya Yagi-Tomita, Noriyuki Yamashita, Keiichi Tamagaki, Benjamin D. Humphreys, Satoaki Matoba, Tetsuro Kusaba   +17 more
doaj   +1 more source